Lions quarterback Jared Goff threw for 236 yards and three touchdowns as Detroit crushed the Carolina Panthers 42-24.

Tua Tagovailoa threw for 308 yards and two touchdowns as the Dolphins, defeated the struggling New York Giants 31-16.

The Lions dominated from the outset with two touchdowns in the first quarter -- a 43-yard rush from David Montgomery and a four-yard pass from Goff to Sam LaPorta.

LaPorta connected on another touchdown pass, from 31 yards, in the second quarter to make it 28-7 and the Lions never looked back from then on.

Miami's offense has been on fire this season and they put themself in charge with a first quarter touchdown catch from Jaylen Waddle and extended their advantage early in the second with a brilliant 76-yard rush from De'Von Achane.

Tagovailoa found Tyreek Hill with a 69-yard pass at the start of the third and and made sure of the win with Raheem Mostert's two-yard rush.

Houston Texans quarterback C.J Stroud set a new record for passes without interception at the start of his career when he reached 177 passes without being picked off.

But the Texans fell to a 21-19 loss at the Atlanta Falcons with a game-winning field goal in the final seconds from Koo Younghoe.

The Jacksonville Jaguars secured back-to-back wins in London with an impressive 25-20 win over the Buffalo Bills at Tottenham Hotspur Stadium.

The Bills came into the game on the back of a three-game winning streak but Jags running back Travis Etienne rushed in two touchdowns in the fourth quarter to take Jacksonville to 3-2 on the season.

Jaguars quarterback Trevor Lawrence threw for 315 yards and a touchdown while his counterpart Josh Allen put up 359 passing yards and threw a second-quarter touchdown pass before a late three-yard rush as the Bills tried in vain to fight back.

The miserable season for the New England Patriots continued with a 34-0 home loss to the New Orleans Saints leaving Bill Belichick's team with a 1-4 record.