Hurts completed 14-of-21 passes for 108 yards and ran eight times for 59 yards as the Eagles (11-2) held off stubborn Carolina 22-16 and stretched their win streak to nine games while the Panthers slid to 3-10.
NFL rushing leader Saquon Barkley, who ran 20 times for 124 yards, set the Eagles one-season rushing record, breaking by 15 yards the old mark of 1,607 yards set by LeSean McCoy in 2013.
Hurts scored on a one-yard plunge early in the second quarter and connected with DeVonta Smith on a 4-yard touchdown pass 14 seconds before half-time for a 14-10 lead.
After the Panthers grabbed the lead on Chuba Hubbard's 1-yard touchdown run in the third quarter, the Eagles answered early in the fourth, scoring the deciding points on a four-yard Hurts touchdown pass to Grant Calcaterra and a two-point conversion run by Barkley.
Rams vs. Bills
Matthew Stafford threw for 320 yards and two touchdowns and Kyren Williams ran for 87 yards and two touchdowns on 29 carries for the Rams in the team's 44-42 shootout win over the Buffalo Bills.
Wide Receiver Puka Nacua had 12 receptions, 162 yards, and one touchdown while Cooper Kupp posted five receptions for 92 yards and a touchdown. The Rams now improve to 7-6 on the season as they keep their division title hopes alive.
Buffalo's Josh Allen scored a career-high six touchdowns (three passing, three rushing) with 424 total yards but couldn't rally the Bills.
The Bills fell to 10-3, a key stumble in their bid to catch Kansas City (11-1) for home-field advantage in the AFC play-offs, even with Buffalo owning a tie-breaker edge after inflicting the Chiefs' lone defeat this season.
The two teams combined for a total of 902 yards, 53 first downs, and 16 total penalties. The 86 combined points are the most in any game this season.
Vikings vs. Falcons
At Minneapolis, Vikings quarterback Sam Darnold completed 22-of-28 passes for career highs of 347 yards and five touchdowns to power Minnesota over the Atlanta Falcons 42-21. Darnold's 157.9 passer rating is a single-game record for the Vikings.
Minnesota hasn't seen a quarterback toss five touchdowns in a game for them since 2004 when Daunte Culpepper did it in three different games.
The Vikings spoiled the return of ex-Minnesota quarterback Kirk Cousins, who threw for 344 yards but was intercepted twice.
The Eagles sealed their play-off spot when Seattle won 30-18 at Arizona behind 134 rushing yards and two touchdowns by Zach Charbonnet.
That left Minnesota needing only a loss by the Los Angeles Rams to clinch a post-season trip, but the Rams held off a fourth-quarter fightback to beat Buffalo.
Around the league
Miami's Tua Tagovailoa threw a 10-yard touchdown pass to Jonnu Smith in overtime to give the Dolphins a 32-26 home triumph over the New York Jets.
The Pittsburgh Steelers improved to 10-3 as Russell Wilson threw for two touchdowns and Najee Harris ran for another in a 27-14 home victory over Cleveland.
Baker Mayfield threw for 295 yards and three touchdowns to spark the Tampa Bay Buccaneers over visiting Las Vegas 28-13.
At San Francisco, Brock Purdy threw for 325 yards and two touchdowns and Isaac Guerendo ran for two touchdowns to give the host 49ers a 38-13 victory over Chicago.
Derek Carr threw for 219 yards and a touchdown as the New Orleans Saints edged the host New York Giants 14-11 while Tank Bigsby's eight-yard touchdown run with 6:46 remaining gave Jacksonville a 10-6 victory at Tennessee.