The stand-off, in for Geronimo Prisciantelli, is one of five changes to Sunday's starting side that helped the Pumas fielded at Murrayfield last weekend, where they came from 21-0 behind to beat Scotland 33-24 on the back of five tries in the closing 23 minutes.
Justo Piccardo replaces Santiago Chocobares in midfield, Bautista Delguy takes over from Mateo Carreras on the left wing, while Marcos Kremer starts at openside flanker, with new No 8 Santiago Grondona and Juan Martin Gonzalez changing positions in a back row without Joaquin Oviedo.
Up front, prop Thomas Gallo packs down alongside Argentina captain and former Leicester hooker Julian Montoya.
Bath playmaker Santiago Carreras, one of 10 men in the Pumas match-day 23 with English Prem clubs, remains among the replacements, after he made a huge impact off the bench from the bench in Edinburgh.
The Pumas are bidding to complete an unbeaten tour of Britain, with a record 52-28 thrashing of Wales in Cardiff earlier this month preceding their comeback win over Scotland.
But they will be up against an England side bidding for an 11th win in a row, a sequence that includes two victories away to Argentina -- 35-12 and 22-17 -- in July.
Argentina (15-1)
Juan Cruz Mallia; Rodrigo Isgro, Matias Moroni, Justo Piccardo, Bautista Delguy; Tomas Albornoz, Simon Benitez Cruz; Santiago Grondona, Marcos Kremer, Juan Martin Gonzalez; Pedro Rubiolo, Guido Petti; Pedro Delgado, Julian Montoya (capt), Thomas Gallo
Replacements: Ignacio Ruiz, Boris Wenger, Tomas Rapetti, Franco Molina, Pablo Matera, Joaquin Oviedo, Agustin Moyano, Santiago Carreras
Coach: Felipe Contepomi (ARG)