The league's last four undefeated clubs topped a busy 11-game slate.
Philadelphia guard Tyrese Maxey scored 43 points and Bahamian rookie guard VJ Edgecombe added 26 to lead the 76ers (3-0) to a 136-124 home triumph over Orlando.
"He's elite, man," Edgecombe said of Maxey, his partner in the NBA's top-scoring backcourt starters through three games. "Very versatile, super fun guy to play with."
Edgecombe, the third pick in this year's NBA Draft, added a spark as Cameroonian big man Joel Embiid was benched by the Sixers for left knee injury management.
"It's a must-win every night," Edgecombe said.
Oklahoma City got 23 points from reigning NBA Most Valuable Player and scoring champion Shai Gilgeous-Alexander plus 18 points and 11 rebounds from Chet Holmgren in a 101-94 victory at Dallas.
The Mavericks outscored Oklahoma City 25-14 in the fourth quarter but could not rally for the win.
D'Angelo Russell's floater lifted Dallas within 95-94 with 54.8 seconds remaining but Isaiah Hartenstein answered with a layup to give the Thunder a 97-94 edge.
Russell missed an attempted tying three-point shot and Holmgren rebounded for Oklahoma City, setting up two free throws by Gilgeous-Alexander with 21.3 seconds remaining.
Gilgeous-Alexander rebounded a Dallas three-point miss and Holmgren sank to final free throws to clinch the Thunder victory to reach 4-0.
Victor Wembanyama continued his strong start to the 2025-26 campaign, scoring 24 points and grabbing 15 rebounds to lead San Antonio's 121-103 home triumph over Toronto.
Stephon Castle added 22 points for the Spurs, who improved to 4-0.
Chicago's Ayo Dosunmu scored 21 points to lead eight Bulls double-digit scorers in a 128-123 home victory over Atlanta.
Dosunmu hit 7-of-10 shots, 4-of-6 from three-point range, while Nikola Vucevic added 17 points, 17 rebounds and nine assists and Josh Giddey contributed 18 points and 13 rebounds for the Bulls, who improved to 3-0.
Kristaps Porzingis led the Hawks with 27 points.
Cleveland's Donovan Mitchell scored 35 points and Jarrett Allen added 20 to lead the Cavaliers' 116-95 romp at Detroit while reserve Tari Eason had 22 points and Alperen Sengun added 21 to power Houston's 137-109 home rout of Brooklyn.
Anfernee Simons scored 25 points off the bench and the Boston Celtics cruised to victory 122-90 at New Orleans.
Later games saw Phoenix at Utah, Denver at Minnesota, Memphis at Golden State and Portland at the Los Angeles Lakers.