The commission upheld almost all of the 115 charges against City, which cover the 2009/10 to 2017/18 seasons, and the club have lodged an appeal while sanctions are still to be decided.
UEFA, whose own 2020 ban on City was overturned on appeal, has confirmed it is monitoring the case and will decide whether to take action of its own once the Premier League process has run its course.
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Today's headlines:
Trip to Atletico a timely reminder of Man Utd's post-Ferguson downfall
Belgium's ambitious Club Brugge ready to take on Inter in Champions League
In-form De Bruyne determined to secure European redemption for Napoli
So far City have answered on the pitch, with a 3-0 win at Anfield on Sunday, which is one way to change the subject.
Four other English clubs are in action in a round that has taken more than a month to arrive, because the new international break format has pushed matchday two well into October. Their moods range from Aston Villa, who are thriving in Europe, to whatever is going on at Old Trafford.
Arsenal vs Lille (Tuesday, 20:00 BST)
Arsenal have made the league phase look like a formality, with 13 straight wins at this stage, and Lille are not obvious candidates to spoil it.
The French side have lost their last seven Champions League games against English opposition and have gone 12 away matches in the competition without a clean sheet.
Most of the intrigue belongs to Olivier Giroud, who returns to the Emirates at 40 with the chance to become only the third player to score both for and against the Gunners in the Champions League. Five of his last six goals in the competition came between the 40th and 60th minutes, so anyone planning an early half-time trip to the kiosk has been warned.
Atletico Madrid vs Manchester United (Tuesday, 20:00 BST)
Europe is the one part of Manchester United's season nobody has booed. Six straight league phase wins, including last month's 4-0 over Sabah, look odd next to the club's worst start to a league season in 40 years and Saturday's draw with 10-man Tottenham, which left Michael Carrick's side booed off at half-time and again at full-time.
A trip to the Metropolitano is not an obvious cure as United have not won away all season and have never beaten Atletico in four attempts (D2, L2).
Sevilla are the only side United have faced more than four times in Europe without beating, and Diego Simeone would be quite happy to add Atletico to that list.
LASK v Liverpool (Wednesday, 17:45 BST)
Liverpool's first defeat under Andoni Iraola was a 3-0 hammering by Man City at Anfield on Sunday, with Cody Gakpo, Dominik Szoboszlai and Alexander Isak all missing. LASK, on paper at least, are a gentler proposition.
They have gone nine group or league phase games in UEFA competition without a win, and no Austrian club has beaten English opposition in major European competition since 1991, a run of 34 matches (D7, L27).
Liverpool have not been involved in a goalless draw in 82 group or league phase games, so whatever happens in Linz is unlikely to be dull.
Aston Villa vs Fenerbahce (Wednesday, 20:00 BST)
In the Premier League, Aston Villa are in the bottom half after Saturday's 2-2 draw with Brentford, but in Europe nobody has won more matches since the start of last season (14), and they have won their last 10 at home.
Fenerbahce arrive with three straight clean sheets and 11 goals in their last two league games, but they have also gone eight Champions League matches without a win and trailed at half-time in eight of their last 10, which is not a habit that tends to end well at Villa Park.
Marco Asensio, briefly a Villa player in 2025, can become the first man to score both for and against them in the competition.
Manchester City vs Paris Saint-Germain (Wednesday, 20:00 BST)
On the pitch, City look like a side who have stopped reading the newspapers, with eight straight wins, top spot in the league and one defeat in their last 25 home matches in the Champions League group or league phase.
Reigning champions PSG have recovered from a sluggish domestic start to win four in a row, and they are unbeaten in 11 Champions League games, with Ousmane Dembele and Nuno Mendes both set to be back. The venue is the holders' problem, because they have never won at the Etihad (D1, L3) and have lost on each of their last three visits.
Galatasaray vs Barcelona (Tuesday, 20:00 BST)
Barcelona have won all nine games at home and in Europe this season, the first time they have started a campaign that way since 1935/36, and they average almost three goals a game in the Champions League under Hansi Flick.
The catch is at the other end, where they have not kept a clean sheet in the competition since the start of last season. That feels like a bit of an open invitation to Victor Osimhen, who has seven goals in 10 Champions League games for Galatasaray.
Raphinha is out for Barcelona, and Galatasaray's home form carried them to the last 16 last season, but history points one way: their only win over Barcelona in 10 meetings came all the way back in 1994.
Roma vs Real Madrid (Wednesday, 20:00 BST)
Roma have waited more than seven years for a Champions League night at home, and they could have hoped for a kinder guest than behemoths Real Madrid.
Gian Piero Gasperini's side have not won in four European games and are without keeper Mile Svilar.
Madrid have won the last four meetings without conceding, although they have lost four of their last eight Champions League away games, so Roma have some cause for hope.
Viking vs Bayern Munich (Tuesday, 20:00 BST)
Bayern Munich are the first side to open a European Cup or Champions League campaign against two Norwegian clubs, which gives their autumn an unexpectedly Scandinavian look. After dismantling Bodo/Glimt 5-0, they head to Stavanger for the first league phase game at Viking's Lyse Arena.
Viking have won their last 11 at home, which is admirable, but they have won only once in 13 matches in the Champions League proper, which is the more relevant number.
Vincent Kompany's side have scored at least twice in nine of their last 10 away games in the competition.
The rest of the round
Lens host Sporting CP and Sabah meet Slavia Prague in Tuesday's 17:45 BST kick-offs. Later that night, Inter and Club Brugge both look for their first points, RB Leipzig host PSV Eindhoven after a 4-1 defeat at Como, and Villarreal face Napoli.
On Wednesday, Feyenoord, still smarting from a 5-1 defeat in Barcelona, play that same Como side. Bodo/Glimt host Borussia Dortmund, Real Betis welcome Porto, Shakhtar Donetsk meet AEK Athens and Stuttgart travel to Slovan Bratislava, who will be hoping for a quieter evening than the 6-1 defeat they suffered in Paris.