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Arsenal aim to go one better than last season's efforts when finishing as UEFA Champions League runners-up behind PSG.
Mikel Arteta's campaign continues with a home match against French Ligue 1 side Lille at the Emirates Stadium, a showdown you can follow live on TV. The Gunners are pre-match betting favourites to shoot down the Mastiffs, but will they hit the target?
Trusted football betting pundit Frank Monkhouse has studied the stats, measured the head-to-head, and unpacked the latest squad news. Keep reading as he lays out his three Arsenal v Lille Champions League predictions and best bets.
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Arsenal vs Lille betting tips
Arsenal win to nil @ 10/11 (bet365)
Odds courtesy of bet365. Correct at the time of publication and subject to change.
Total goals - Over 2.5
I open with a bet on Arsenal v Lille to produce more than two goals from both teams combined.
The beauty of this bet is that the winning team and goalscorers don't matter; a 3-0 home win pays the same as a 2-2 draw or a 2-1 away win. As long as the game delivers at least three goals, followers will boost their betting balance.
Arsenal began their Premier League season with a 3-0 win over Coventry City and went two from two at this venue, beating Chelsea 2-1 in an entertaining London derby. They then edged Leeds United 2-1 here on Saturday.
On UCL matchday one, Arsenal secured a valuable 1-0 win over Napoli in Italy. They dominated possession that evening, had an incredible 26 shots at goal, and 51 touches inside the opposition box. The final scoreline flattered Massimiliano Allegri's team.
Arteta and the home fans will demand more clinical finishing at home, and I'm confident they'll turn chances into goals. The team is fitter and sharper than they were five weeks ago. Arsenal scored an average of three goals per game in three starts since to finish September on a high. There's better to come from this side.
Lille began their Champions League adventure with an entertaining 3-2 defeat to Real Betis. Davide Ancelotti's team played four games last month, averaging 2.75 goals per game. A bet on over 2.5 goals landed in two of their previous three outings.
Tip: Over 2.5 goals @ 4/7 (bet365)
Bet explanation: Arsenal vs Lille must produce more than two goals from both teams combined. If it does, your bet lands at a fair price.
Win to nil - Arsenal
Moving to my second pick, and I'm taking Arsenal to win in style.
Arsenal to beat Lille has been chalked up at 2/9 by the bet365 traders. I certainly wouldn't put anyone off that one, especially in midweek accumulators, but I am confident we can do better and shoot for a more exciting price.
Arsenal to win to nil is 10/11, and that's worth a play.
The clue is in the name: your stake rides on Arsenal beating Lille and keeping a clean sheet in the process. Another 1-0 UCL win pays the same as a 5-0 demolition, but why am I so confident backers will get their money's worth?
Lille have lost each of their last seven Champions League matches against top-tier English sides. You can trace that run back to 2005 when the Ligue 1 side beat Man Utd 1-0.
It's also worth knowing that Arsenal haven't lost a home match to French opposition in the group or league phase of this tournament in seven games, winning five and drawing two. Three of those games have come during Arteta's reign, producing an 11-0 aggregate score.
I'll now remind my readers of Arsenal's form on route to last season's Champions League final. The Gunners failed to concede against Athletic Bilbao, Olympiakos, Atletico Madrid, Slavia Prague, Club Brugge, Bayer Leverkusen, and Sporting. They also beat Atletico 1-0 here in the semi-finals.
Lille were involved in the Europa League last term. They failed to score when visiting Red Star Belgrade, Young Boys, and Aston Villa.
Tip: Arsenal win to nil @ 10/11 (bet365)
Bet explanation: Both parts of this bet must land. Arsenal must win, and Lille must leave London without scoring.
Score - Saka
My final Arsenal v Lille Champions League prediction comes from bet365's player betting markets. I'm advising an interest on vice-captain Bukayo Saka to lead by example and score at least one goal.
You can aim higher and bet the Londoner to open the scoring at 11/8, but the anytime scorer option covers you for the entire time he's on the field of play. A showreel goal inside the opening five minutes is as good as a late tap-in.
The stats show that Saka has been involved in 14 goals in the last 14 Champions League games he's played in at this stadium. That's nine goals and five assists.
Against Napoli, he had six shots at goal and created one chance in his 73 minutes of action. Domestically, he opened his account for the season with a goal against Coventry City, then scored again at Villa Park and a third at the Stadium of Light.
Last season, Saka scored UCL goals against Olympiakos, Slavia Prague, and Atletico Madrid. Let's not forget that stunning hat-trick against France in the World Cup 2026 bronze medal playoff.
The odds on Saka scoring make it best for a single bet, but you can also add it to your Arsenal v Lille Bet Builders.
Tip: Saka to score @ 11/8 (bet365)
Bet explanation: If Saka scores at any time during the live match with Lille at the Emirates Stadium on Tuesday evening, this bet wins.
Arsenal vs Lille betting odds
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