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Having won both of their previous meetings with Newcastle at the Camp Nou, Barcelona possess the superior head-to-head record in this fixture. The Blaugrana will also be buoyed by their recent scoring exploits, after netting in 16 consecutive Champions League outings at an average of 3.1 goals per game.
Their progress on both domestic and continental fronts this season has been aided by the attacking contributions of Raphinha and Lamine Yamal, who continue to rip apart opposition defences at will.
Club captain Raphinha claimed a hat-trick during Sunday's resounding victory over Sevilla, while Yamal has registered 12 direct goal involvements in his last 11 home appearances.
Newcastle are aiming to break a rotten sequence of results on Spanish soil, having lost five of their last six away fixtures against La Liga opponents.
Nevertheless, the Magpies haven't tasted defeat on European duty since last November's 2-1 loss to Marseille and also boast several exceptional attacking talents.
If Anthony Gordon and Harvey Barnes can continue their excellent efforts in the final third, Newcastle could become the first club to have two English players record more than ten direct goal involvements during a single Champions League campaign.
Although he's performed consistently well throughout the campaign, Lewis Hall delivered a particularly strong display in last week's first leg. The industrious full-back created six chances, completed three line-breaking passes, and recovered possession on seven separate occasions.
Barcelona v Newcastle – Predictions
Barcelona to win: 11/20 (bet365)
Barcelona - Goals Range 2-5: (bet365)
Odds valid at the time of publication, subject to change.
Barça to progress to the quarter-finals
Despite having to play at the Estadi Olímpic Lluís Companys and Johan Cruyff Arena while the Camp Nou was still under renovation at the beginning of the campaign, Hansi Flick's men have been virtually flawless on home soil this term. In addition to winning all 14 of their home league fixtures, they've averaged 3.25 goals per game across four Champions League outings in Catalonia.
It's also worth noting that Barça have progressed to the next round on each of the last ten occasions they've drawn the first leg of a European knockout tie.
Meanwhile, Newcastle United are burdened by an extensive injury list. The most notable absentee is influential midfielder Bruno Guimarães, who is a vital cog in Eddie Howe's well-oiled machine.
The Magpies are undoubtedly a tough nut to crack, but Barcelona's ability to dictate the pace and tempo of the play may prove decisive. On average, the Catalans have enjoyed 60.78% possession across their nine European contests, while finding a teammate with 88.45% of their passes.
Can Barça make their time on the ball count?
Prediction: Barcelona to win: 11/20 (bet365)
Explanation: This bet lands if Barcelona win the match. Please note that this bet will not be successful if the hosts require extra time or penalties to win the tie - they must be ahead at the end of regulation time.
Goals galore?
With both teams keen to drive forward at every given opportunity and Barcelona's defensive frailties regularly being exposed in Europe of late, there's a good chance we'll see a high-scoring encounter on Tuesday night.
Although they've already netted 23 goals on Champions League duty this term, the Blaugrana have also failed to keep a single clean sheet in UEFA's most prestigious competition.
Newcastle United also see plenty of action in both boxes. Both teams have scored in each of the Magpies' last 12 matches, while they've netted an average of 2.46 goals across their five away fixtures in this season's Champions League.
Eddie Howe's men have largely relied on the finishing capabilities of English duo Anthony Gordon and Harvey Barnes, who have combined to net a staggering 16 Champions League goals so far.
Given the attacking quality on show, Joan García and Aaron Ramsdale could both in for a busy evening at the Camp Nou...
Prediction: Over 2.5 Goals: 4/11 (bet365)
Explanation: This bet will land if three or more goals are scored during the match, regardless of the final result.
Selecting the right range
Having averaged exactly 2.75 goals per game during the opening phase of this season's Champions League campaign, it's clear that Barcelona are equipped with a lethal forward line.
The Blaugrana have generated an eye-watering 452 attacks across their nine European outings this term, enabling the likes of Lamine Yamal, Raphinha, and Robert Lewandowski to carve out a consistent flow of goalscoring opportunities.
Eddie Howe is currently without the services of defensive duo Fabian Schär and Emil Krafth, so Newcastle are a little vulnerable at the back.
Although they've kept four clean sheets out of their opening eleven Champions League contests, the Magpies will likely struggle against a team that has already netted 72 goals in just 27 LaLiga outings this term.
Barça have recently recorded 4-1, 3-0, and 3-1 victories over several different opponents, so don't be surprised if this match also witnesses a similar amount of goals.
Prediction: Barcelona - Goals Range 2-5: 4/9 (bet365)
Explanation: This bet lands if Barcelona score exactly two, three, four, or five goals in regulation time.
Barcelona v Newcastle United: Match result odds
Odds valid at bet365 at the time of publication, subject to change.
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Odds valid at the time of publication, subject to change.