Wednesday night's tie at the Allianz Arena is finely poised after last week's frantic 2-2 draw in London.
Visiting Bayern were pegged back in the second half but also picked up a handful of squad concerns in the process.
But it's at left-back where Tuchel has some key thinking to do with Alphonso Davies suspended.
Tasked to contend with Saka in the first leg, the Canadian had a mixed bag as he was cautioned less than 10 minutes into proceedings.
It came after a clumsy foul on the Arsenal winger, but Davies gathered himself and put in a much better display as the game went on.
With his suspension, Tuchel now has a big decision to make with Bayern well aware of the threat posed by Saka.
According to Bild, the German coach is set to bring Noussair Mazraoui into the fold, while natural left-back Raphael Guerreiro will also play but in an advanced role.
It is claimed the pair took part in Bayern's 'A team' training drills on Tuesday while Thomas Muller was in the 'B team', suggesting he will start from the bench and Jamal Musiala will take up the role behind Harry Kane.
Tuchel deployed both of Mazraoui and Guerreiro in Bayern's win over Cologne with the latter, who scored in the 2-0 victory, given a more inverted position in midfield.
The decision field both players on Wednesday will likely be down to having some focus on restraining Saka, who has plenty of ability to deal damage from out wide.
It would also be a bitter pill to swallow for Muller on the flip side, with the long-time Bayern man excellent in Saturday's win.
Victory for either side in Munich will see them set up a semi-final clash with one of Manchester City and Real Madrid with their quarter-final tie also in the balance after a 3-3 first-leg draw.