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After intense first-leg encounters, teams will be looking to secure their spots in the quarter-finals, making this a pivotal moment in the tournament.
We dive into the stats, analyse the odds, and make some savvy bets as we break down the potential outcomes of selected matches.
Barcelona – Benfica, Tuesday, 5:45 pm
With Benfica facing a challenging second leg after their 1-0 defeat at home, they have no choice but to adopt an aggressive approach from the onset.
Barcelona, currently the highest-scoring team in the tournament, is poised to exploit any gaps left by Benfica's attacking efforts.
The odds for over 2.5 goals on bet365 stand at an appealing 33/100, making it an enticing option. Although Barcelona had to play conservatively due to an early red card to Pau Cubarsi in their last match, with a full squad available, fans can expect a more dynamic attacking display this time around
Bet explanation: The bet wins if 3 or more goals in total are scored in the match, no matter who scores.
Bayer Leverkusen – Bayern Munich, Tuesday, 8:00 pm
With Bayern Munich entering this match with a commanding 3-0 lead from the first leg, the challenge for Bayer Leverkusen has become even steeper, especially following Florian Wirtz's injury.
Nevertheless, the home crowd will rally behind Leverkusen, who have a solid record against Bayern under Xabi Alonso, remaining unbeaten in their last three home encounters with two victories and one draw.
Interestingly, Bayern has experienced two away defeats in the UEFA Champions League this season by three-goal margins (1-4 to Barcelona and 0-3 to Feyenoord), which could offer Leverkusen a glimmer of hope. While it may be difficult for them to qualify, they will certainly be motivated to secure a win on home soil.
Tip: Bayer Leverkusen to win @17/10
Bet explanation: The bet wins if Bayer Leverkusen wins the match against Bayern Munich within regular time.
Liverpool – PSG, Tuesday, 8:00 pm
Liverpool showcased a new side under Arne Slot, emerging from Paris with a hard-fought 1-0 victory despite being largely outplayed by PSG and relying heavily on Alisson's remarkable saves.
The Reds adopted a pragmatic strategy, managing just 29% possession and only two shots throughout the match. With this slender lead, it remains uncertain which approach Liverpool will take to the field at Anfield.
On the other hand, PSG continues to exude confidence, having demonstrated their attacking prowess by scoring four goals against Rennes over the weekend. Therefore it may be wise to adopt a wait-and-see approach for this matchup.
Tip: No bet
Arsenal – PSV, Wednesday, 8:00 pm
Arsenal are just a different side when it comes to the Champions League this season. They have truly transformed in this season's Champions League, winning all four of their home matches without conceding a single goal.
The odds for an Arsenal victory currently sit at 2/5 on bet365, which seems surprising given their dominance in the competition. With a commanding 7-1 lead, PSV faces an uphill battle and is likely to struggle against Mikel Arteta's formidable side once again.
While the Premier League title has eluded Arsenal, the Champions League presents a genuine opportunity, and they are determined to seize it with both hands.
Bet explanation: The bet wins if Arsenal wins the match against PSV within regular time.
Aston Villa – Club Brugge, Wednesday, 8:00 pm
Although Club Brugge may have been the last team to qualify for the knockout stage, their performances have proven they deserve respect. A stunning 5-2 victory over Atalanta showcased their potential.
However, they now face a daunting challenge after falling 3-1 to Aston Villa, who will have the advantage of playing in front of their home crowd. While a win may be difficult for Brugge, you can confidently bet on them to score.
The odds for Brugge to find the net are set at 11/25 on bet365, which is attractive considering they have only failed to score in three games this season.
Tip: Club Brugge total goals over 0.5@11/25
Bet Explanation: This bet wins if Club Brugge scores at least one goal against Aston Villa. The result of the match doesn’t matter.
Atlético de Madrid – Real Madrid, Wednesday, 8:00 pm
With just a single goal separating Atletico Madrid and Real Madrid, there's still plenty at stake in this thrilling encounter. Atletico will enter the match with confidence, having lost only one of their last seven home games against their rivals in all competitions. In fact, they remain unbeaten in their last five home cup matches against Real, winning four and drawing one.
Historically, Atletico has been formidable at home in UEFA Champions League knockout matches, not losing at either the Vicente Calderón or Metropolitano Stadium since a 3-2 defeat to Ajax in March 1997. They are currently on an impressive 18-match unbeaten streak in such fixtures (W11 D7).
While playing at home could tilt the tie in Diego Simeone's favor, Real Madrid's unpredictability in the Champions League adds an intriguing twist. The odds of 3/2 on bet365 for an Atletico Madrid victory may seem appealing, but for a safer bet with good value, consider backing Atletico to win or draw at 11/25.
Tip: Atletico Madrid or draw @11/25
Bet Explanation: This bet wins if Atletico Madrid wins or draws against Real Madrid in regulation time.
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The odds, correct at the time of publication, are subject to change.