The fifth-placed Eredivisie side impressed against Turkish giants Galatasaray, beating them 4-1 in Alkmaar before limiting the damage in Istanbul with a 2-2 draw.
In their first UEFA Europa League round of 16 appearances since the 2013/14 season, AZ will face Manchester United or Tottenham Hotspur.
The Cheeseheads have met both teams before but met Tottenham Hotspur most recently, narrowly losing 1-0 at Tottenham Hotspur Stadium earlier this season thanks to a Richarlison penalty.
AZ and Manchester United have only met twice before - during the 2019/20 Europa League season. AZ held the Red Devils to a 0-0 draw in Alkmaar but lost 4-0 at Old Trafford in December 2019.
Tottenham Hotspur and Manchester United have been struggling this season, with both sides in the bottom 10 of the Premier League. However, both teams also finished in the top 4 in the league phase of the Europa League with Manchester United finishing third and Tottenham Hotspur fourth.
The draw for the UEFA Europa League round of 16 will take place on Friday, February 21st at 13:00 CET in Nyon, Switzerland