Wigan are currently without a manager and find themselves in the relegation zone, just two points off rock bottom as they come head to head with the Premier League and Champions League leaders.
The Gunners will welcome the League One side to the Emirates Stadium for the first time since the FA Cup semi-final in 2014 in what should be an entertaining clash.
Why have Arsenal struggled in the FA Cup?
Arteta first spoke on his side not making it past the fourth round of the FA Cup since winning it six years ago and if that is a squad depth issue.
“Or we haven't been good enough on that day. And when you come to a competition, you have to be excellent on the day and the rest, the shirt that you wear or the shorts that you wear is irrelevant. So we're going to have to prove that against Wigan again on Sunday.
"It's an opportunity for the team (to bounce back). Again, with another competition and the history that we have related to that competition, it's amazing. We play at home again and I'm really excited to recover and go again."
Arsenal will rotate
Arteta next admitted that the FA Cup could be a welcome break from the Premier League in which Arsenal dropped points against Brentford on Thursday night.
“We are doing that every week, every three days we are playing different competitions, so we are so used to it.
“We reflect on the game, take the positives, the learnings for sure that we have to improve, and go on Sunday again with the energy and the batteries fully charged to win the game.
“Yes, (changes will be made) that's what we've been doing, trying to make sure that everybody is a big part of what we are doing in different competitions, and Sunday will be the same.”
The Premier League leaders also in the EFL Cup final as they chase down every competition possible under Arteta who seems hellbent on proving many doubters wrong this season after years of failing to lift silverware.