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Following a recent 5-1 defeat against Arsenal in the Premier League, Manchester City will be aiming to bounce back and secure their place in the fifth round.
City easily overcame League Two side Salford City in the last round with an 8-0 victory, but Leyton Orient at Brisbane Road will be a different challenge.
Leyton Orient, currently sixth in League One with 44 points, have only lost twice in their last 16 games.
Manchester City, sitting fifth in the Premier League, have lost six of their last 16 matches and conceded 27 goals, giving Orient some hope for the weekend match.
This marks Leyton Orient's first appearance in the FA Cup fourth round since 2010/11. They have won their last five home games in the FA Cup and will aim to build on that form.
Leyton Orient v Man City key info
Date: Saturday, February 8, 2025
Kick-off time: 8:00 PM GMT
Venue: Brisbane Road, London
Referee: Darren Bond (on pitch)
TV channels: BBC iPlayer (Gbr), BBC One (Gbr), BBC Radio 5 Live (Gbr), BBC Radio (Gbr), BBC Sport (Gbr)
Odds: Leyton Orient – 16/1 | Draw – 10/1 | Manchester City – 11/100
Leyton Orient team news
Leyton Orient will go into this crunch fixture against Manchester City with a relatively healthy squad, though they face some injury concerns.
Jordan Graham remains sidelined with a knee injury, while Omar Beckles is likely to miss out due to a hamstring issue.
The likes of Dan Agyei, Jack Simpson, and Ollie O'Neill also remain on the sidelines due to injury.
These absences could force manager Richie Wellens to reshuffle his defensive lineup.
Leyton Orient expected lineup v Manchester City (4-2-3-1)
Coach: Richie Wellens
Keeley; James, Cooper, Happe, Currie; Pratley, Brown; Perkins, Donley, Abdulai; Kelman
Man City team news
For the first time in a long while, Pep Guardiola has the full complement of his squad bar Rodri who is out long term.
Oscar Bobb is nearing a return after a six-month layoff and has been involved in multiple training sessions with the first team.
On a positive note, Ederson, Ruben Dias, Nathan Ake, and Jeremy Doku have all recently returned to first-team training. However, their availability for Saturday's game is still uncertain.
City made several signings during the January transfer window, including Abdukodir Khusanov, Vitor Reis, and Nico Gonzalez, who could feature in this match.
Manchester City expected lineup v Leyton Orient (4-2-3-1)
Coach: Pep Guardiola
Ortega; Lewis, Khusanov, Reis, O'Reilly; Gundogan, McAtee; Savinho, De Bruyne, Grealish; Mubama
H2H record
Manchester City's recent form has been inconsistent, with a shocking 5-1 defeat against Arsenal in their last Premier League match.
This loss ended a six-match unbeaten run in the league. However, they started their FA Cup campaign with a dominant 8-0 victory over Salford City.
Leyton Orient, currently sixth in League One, has been in excellent form. They were unbeaten in 12 matches, winning ten, before a narrow 1-0 defeat to Stockport County last Saturday.
The O's have shown resilience in the FA Cup, progressing through three rounds with two penalty shootout victories
Manchester City and Leyton Orient will face off for the first time since 1966. In their prior FA Cup meetings, Manchester City emerged victorious on both occasions, with scores of 4-1 in 1920 and 6-1 in 1926.
Odds for Leyton Orient and Man City
Manchester City have thrown in the towel in the Premier League title race and can now realistically only win the FA Cup and Champions League this season.
Guardiola will rotate his squad but retain enough quality to dominate a Leyton Orient side in the third tier of English football.
According to bet365, the odds for a Leyton Orient win are 16/1, 10/1 for a draw, and 11/100 for a Manchester City win.
Odds, correct at the time of publication, are subject to change.