Second-tier FA Cup giant-killers Plymouth Argyle drew a fifth-round game at reigning Premier League champions Manchester City on Monday as a reward for their shock 1-0 defeat of Liverpool at the weekend.
Holders Manchester United will host Fulham in an all-Premier League clash at Old Trafford while League Cup finalists Newcastle United are at home to top-tier rivals Brighton & Hove Albion.
Bournemouth will host Wolverhampton Wanderers in another all-top-flight encounter.
The fifth-round matches will be played on the weekend of March 1st and 2nd.
Last 16 draw:
Newcastle United v Brighton & Hove Albion
Bournemouth v Wolverhampton Wanderers
Manchester City v Plymouth Argyle
Exeter City or Nottingham Forest v Ipswich Town
Crystal Palace v Millwall