The vibrant neighborhood, a short drive from downtown Miami, has been the centre of the city's creative scene for decades with dozens of its walls colourfully spray painted by international and up-and-coming artists.
And one of its most prominent walls - featuring the Inter Miami quartet of Lionel Messi, Jordi Alba, Fafa Picault and Benjamin Cremaschi - is being replaced.
The wall, which will feature England captain Harry Kane and German duo Jamal Musiala and Thomas Muller, is being prepared in time for Bayern's eagerly anticipated match against South American side Boco Juniors at the Hard Rock Stadium on Friday.
Internationally renowned artist Maxi Bagnasco is behind the latest work.
The Argentinian shot to stardom with a mural of Messi in Albania before depicting the striker in the widely-photographed 'Welcome to Miami' painting in Wynwood in 2023.
The imposing mural, on NW 28th street, hit global headlines when Inter Miami co-owner David Beckham hitched a ride with Bagnasco to see the artwork up-close.
"David Beckham really liked the mural. He wanted to jump into the lift with me and kind of make it seem like he was painting," he told Flashscore.
"But he didn’t paint. (I) was the artist!
"On the news they said ‘David Beckham is painting Messi.’ Victoria Beckham then said 'oh look, my husband is doing a mural.'
"And he wasn’t – (I) was the artist!", he said jokingly.
Among the 43-year-old's other famous works include a striking image of former Argentina star Diego Maradona in Naples, Italy.
When Maradona died in 2000, fans from all over the world congregated around Bagnasco's mural in mourning.
Yet the 43-year-old dismisses his celebrity status and the attention he has received. He doesn't support any football team and is humble when taking credit.
"It's my job," he said. "This (pointing at the wall) is the office."
Christian Romero is a tour guide for Wynwood Buggies and highlights the city's murals to tourists.
The fellow Argentinian moved to Miami 24 years ago and remembers when the area was derelict before artists turned the district into one of the Miami's most famous sights.
"I hope people understand how important the art is. How much impact (it has made) in a positive way," he said.
"Definitely there is a bunch of the most famous artists in the world here. They come here to paint.
"Today, this is the mecca of the art. If you don’t paint it in Wynwood you are no one."
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