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Atlético are effectively out of the title race but will have one eye on this month's Copa del Rey final, while the Catalans look to remain competitive on both LaLiga and continental fronts.
Therefore, it'll be interesting to see how both managers approach Saturday night's contest.
Eager not to give second-placed Real Madrid any encouragement, Barça will be desperate to secure all three points at the Metropolitano.
Hansi Flick’s men are also hoping to avenge last month's Copa del Rey exit, which saw them lose out to Atlético following two thrilling legs of football.
With a European tie between these two Spanish giants just around the corner, a victory for either side could provide a significant psychological advantage heading into their Champions League encounter.
Atlético Madrid v Barcelona – Predictions
Juan Musso/Jan Oblak – Over 2.5 Saves: 8/15 (bet365)
Barcelona - Most Shots: 4/6 (bet365)
Lamine Yamal to win 2+ fouls: 8/15 (bet365)
Odds correct at the time of publication and may change.
Juan Musso or Jan Oblak to make three or more saves
Regardless of who features between the sticks for the hosts on Saturday night, Atléti's defenders know they can rely on their goalkeeper.
Juan Musso has performed exceptionally well this term, registering several clean sheets in the Copa del Rey and providing more than adequate cover for the injured Jan Oblak in recent weeks.
It remains to be seen whether Oblak will be fit enough to feature at the weekend, but Simeone has an able deputy in Musso if the Slovenian isn't ready to return.
Musso has recorded three or more saves in each of his last five appearances. Furthermore, the Argentine has achieved this stat when playing in any match that has produced an adequate (3 or more) volume of shots on target, such as both legs of the Copa del Rey semi-final meeting with Saturday's opponents.
If Oblak does recover in time for the weekend, this prediction could easily still materialise. The 33-year-old stopper has made three or more saves in seven of his ten most recent outings, while the same could be said of his last two appearances against Barcelona.
Clearly, this type of bet requires the opposition to have a sufficient number of shots on target. As Barcelona are currently the Spanish top-flight's top scorers by some distance, we can safely assume that the home goalkeeper will be tested on numerous occasions on Saturday night.
Prediction: Juan Musso/Jan Oblak – Over 2.5 Saves: 8/15 (bet365)
Explanation: This bet lands if Atlético Madrid's goalkeeper – whether that be Juan Musso or Jan Oblak (or a combination of both) – makes three or more saves during the match.
Barça to have the most shots
As well as leading LaLiga's goalscoring charts, Barcelona have delivered the most shots, shots on target, and even shots against the woodwork in the division. The Blaugrana have outstruck their opponents in all but two of their 29 league matches, with away fixtures in the Spanish capital against Rayo Vallecano and Real Madrid being the only exceptions.
Moreover, Barça have recorded more shots than Atlético in each of the last seven meetings between these two sides, including last month's 4-0 thrashing at the Camp Nou.
Therefore, expect the visitors to create plenty of shooting opportunities.
Prediction: Barcelona - Most Shots: 4/6 (bet365)
Explanation: This bet lands if Barcelona record more shots than Atlético Madrid during the match.
Lamine Yamal to draw two or more fouls
As Raphinha will be absent this weekend thanks to an injury he sustained on international duty, so Lamine Yamal will be asked to shoulder the lion's share of attacking responsibility. The talented youngster has been fouled on more than two occasions in four of his last five starts, and in both legs of the recent Copa del Rey semi-final.
Prediction: Lamine Yamal to win 2+ fouls: 8/15 (bet365)
Explanation: This bet lands if Lamine Yamal is fouled on two or more occasions during the match.
Atlético Madrid v Barcelona – Match Result odds
Atlético Madrid: 21/10 (bet365)
Odds correct at the time of publication and may change.
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Odds correct at the time of publication and may change.