Rodrygo returned to action on Monday in the 1-0 loss to Getafe, but after a tussle with an opponent, he fell near the touchline and immediately grabbed his knee. He managed to play for another half hour, but it was clear he wasn’t comfortable.
It is a seismic blow for Madrid, who are also missing Kylian Mbappe with a knee sprain and Franco Mastantuono, who was sent off against Getafe.
The only fit forwards left are Vinicius Jr and Gonzalo Garcia, as well as Brahim Diaz, who doesn’t seem to be in the coach’s plans.
Real are four points behind Barcelona at the summit of La Liga, and have a last-16 meeting with Manchester City in the Champions League on the horizon.
Meanwhile, Brazil have a pair of upcoming friendlies in a few weeks against France and Croatia in preparation for the World Cup.
Manager Carlo Ancelotti must now reshuffle his pack without one of his key players.