The competition runs from December 21st to January 18th, 2026, with players potentially missing up to six Premier League games depending on how far their nation goes.
FIFA recently announced that clubs could keep hold of players up to December 15th before letting them jet off to the tournament.
Several Premier League clubs are set to lose players to AFCON over the winter - here, Flashscore have compiled a list of all the stars set to leave on international duty.
Arsenal - zero players
The Gunners have no players representing African nations in their first-team squad.
Aston Villa - one player
Winger Evann Guessand is a regular in the Ivory Coast squad and has been selected for AFCON.
Bournemouth - one player
Summer signing Amine Adli has been called up for hosts Morocco - but the Cherries will retain star player Antoine Semenyo after Ghana failed to qualify.
Brentford - two players
Dango Ouattara has been called up for Burkina Faso, while Frank Onyeka has been included in Nigeria's squad.
Brighton - one player
Carlos Baleba has struggled this season but remains a part of Cameroon's squad for AFCON 2025/26, while Yankuba Minteh will remain with the Seagulls after Gambia failed to qualify.
Burnley - three players
Lyle Foster has been included in South Africa's squad, while Axel Tuanzebe has been selected for DR Congo.
Hannibal Mejbri is also part of Tunisia's squad.
Chelsea - zero players
Chelsea have no players representing African nations in their first-team squad.
Crystal Palace - one player
The Eagles have several first-team players who could have headed to Morocco, although a few are injury concerns ahead of the tournament.
Chadi Riad (Morocco) and Chieck Doucoure (Mali) are yet to feature for the club this season and will miss AFCON.
Ismaila Sarr (Senegal) went off injured in their December loss to Manchester United, but has been picked for AFCON
Christantus Uche was in Nigeria's preliminary squad, but was not selected for the final tournament.
Everton - two players
Both Iliman Ndiaye and Idrissa Gueye are regulars for Senegal and will join up with the squad before the start of the tournament.
Youngster Adam Aznou was not called up for the hosts, Morocco.
Fulham - three players
Nigerian trio Alex Iwobi, Calvin Bassey and Samuel Chukwueze have all been selected in Nigeria's side.
Leeds - zero players
Leeds have no players representing African nations in their first-team squad.
Liverpool - one player
Star forward Mohamed Salah has, as expected, been called up for Egypt.
Manchester City - two players
Likewise, Omar Marmoush has also been confirmed to be part of Egypt's squad.
Rayan Ait-Nouri has barely featured lately but is expected to join up with Algeria.
Manchester United - three players
Three important players are set to head off to AFCON, with Amad Diallo (Ivory Coast) and Bryan Mbeumo (Cameroon) both confirmed to be heading to the tournament. Noussair Mazraoui was also selected by Morocco.
Newcastle - zero players
Yoane Wissa would normally be part of DR Congo's team, but was not selected due to his current injury struggles.
Nottingham Forest - two players
Taiwo Awoniyi was named in Nigeria's provisional squad, as was Ola Aina, although the defender is expected to be out until January with a hamstring injury - neither was included in their final group.
Both Ibrahim Sangare and Willy Boly have been called up for the Ivory Coast.
Sunderland - six players
Sunderland will be the club most affected by AFCON, with six out of a possible seven players confirmed to depart.
Noah Sadiki and Arthur Masuaku have been added to DR Congo's squad, as has Bertrand Traore with Burkina Faso, while Chemsdine Talbi will join up with Morocco and Reinildo Mandava has been selected for Mozambique.
Simon Adingra will remain at the club after not being included in the Ivory Coast team.
Club record signing Habib Diarra is also set to join up with Senegal despite recovering from a groin injury that has kept him out of action since September.
Tottenham Hotspur - two players
Pape Matar Sarr has been selected by Senegal, while out-of-favour midfielder Yves Bissouma will join up with Mali.
Winger Mohammed Kudus represents Ghana, who didn't qualify for the tournament.
West Ham - two players
The Hammers are set to miss defensive pairing Aaron Wan-Bissaka and El Hadji Malick Diouf. The former has been called up for DR Congo, while the latter has been selected for Senegal.
Wolves - two players
Just two out of a potential five players are set to depart for AFCON, with the club sitting at the bottom of the Premier League.
Marshall Munetsi was not selected by Zimbabwe, but teammate Tawanda Chirewa will go to the tournament.
Emmanuel Agbadou has been named in the Ivory Coast side.
Tolu Arokodare was named in Nigeria's preliminary squad but has not been included in the final side.
Jackson Tchatchoua was not picked by Cameroon for AFCON.