Arne Slot's Reds are on 82 points, putting them out of reach for Mikel Arteta's second-placed Arsenal with four games left.
In doing so, Liverpool have now matched Manchester United's total number of top-flight English titles.
It is Slot's first trophy since taking over as manager from Jurgen Klopp, who helped the team win their first Premier League title in 2020 following a 30-year dry spell.
Their latest Premier League title is Liverpool's second in five years, taking them to a record-extending total of 70 major honours.
"This is the most beautiful club in the world," Liverpool captain Virgil van Dijk told Sky Sports. "We deserve this. We are going to enjoy the next couple of weeks and take it in.
"I was desperate to win it for (the fans) and all the fans around the world, and for us as well.
"We have won two Premier League trophies in five years."
Liverpool raced to a six-point lead at the top with a game in hand over Arsenal before the turn of the New Year.
Both sides stumbled at times over the last few months, but it's Liverpool who have come out on top in the end.
Manchester City were the only other realistic title challengers, but Pep Guardiola's men dropped off after a 2-0 defeat at Anfield on Christmas Eve.
Several players have had a key impact in Liverpool's triumph, including Van Dijk and star forward Mohamed Salah.
The pair also helped Liverpool to success in 2020, but Salah in particular this season has elevated his level of performance to new heights.
The Egyptian netted in Sunday's win over Spurs, taking his Premier League tally this campaign to an impressive 28 goals and 18 assists respectively.
Liverpool will have to wait until the final game of the season at home to Crystal Palace on May 25th to lift the Premier League trophy.