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It's a match that'll attract a capacity crowd at Old Trafford, with millions more fans across Planet Football following the action on television and the best live streaming apps.
Manchester United welcome Liverpool to the Theatre of Dreams with both clubs battling hard for a top-three finish. There's all to play for, ensuring an action-packed 90 minutes.
The head-to-head stats available now on the Flashscore app prove that Saturday will be the seventh time these rivals have crossed paths in the last three seasons.
The results from the previous six show that three were played at Old Trafford, producing a total of 14 goals. Neutrals would dearly love another dramatic goalfest in this weekend's renewal.
You can make Man Utd vs Liverpool even more exciting by placing a well-informed and researched bet on the result.
Our gambling partners offer a deep pool of markets and specials, including first scorer, total goals, and the match-winner.
Keep reading as Flashscore's football betting writer Frank Monkhouse leans on the stats and trends to produce his three best bets.
Man Utd v Liverpool tips
Both teams to score @ 4/9 (bet365)
HT result - Liverpool @ 21/10 (bet365)
Odds courtesy of bet365. Correct at the time of publication and subject to change.
Total goals - Over 2.5
I open with a bet on the totals market, taking over 2.5 goals. If following, you need Man Utd vs Liverpool to produce three or more goals from both teams combined.
It doesn't matter if Man Utd win 3-0, Liverpool 2-1, or it's a stunning 4-4 draw. As long as there are more than two goals in the game, you'll beat the bookies. You can relax and cheer every attack.
The head-to-head stats suggest we'll get a run for our money with this bet. Incredibly, over 2.5 goals landed in each of the last five games involving these teams, a run going back to March 2024.
In those two years, we've seen a good mix of results, including a 3-0 win for Liverpool at Old Trafford and a 4-3 for Man Utd.
Let's now turn our attention to how both the Red Devils and Reds have performed in recent weeks. The home team have won each of their previous two EPL starts, including a 2-1 win over Brentford at this venue.
They did lose by the same scoreline when Leeds were in town. Liverpool have won their last three, scoring seven goals and conceding just two.
Tip: Over 2.5 goals @ 1/2 (bet365)
Bet explanation: If Man Utd vs Liverpool produces more than two goals, your bet wins.
Both teams to score - Yes
Moving to my second suggested bet, and both teams to score looks a solid addition to your weekend multiples, including Premier League accumulators.
Sticking with the H2H stats, we see both teams to score landed when Man Utd beat Liverpool 2-1 at Anfield late last year. A BTTS bet was settled as a winner inside 78 minutes that day, thanks to Mbeumo and Gakpo.
Digging deeper, the last four seasons have given us eight meetings of Man Utd and Liverpool in the Premier League and FA Cup. A bet on both teams to score landed in five of those eight, including in each of the previous two.
Focusing on matches at Old Trafford, BTTS was settled as a winner in two of the last three. It's sure to be a popular bet again.
How have Liverpool performed on their travels this year? Arne Slot's team beat Everton 2-1 in the Merseyside Derby. They also lost to Brighton by the same scoreline, and 2-1 was the result when the defending champions lost at Molineux against bottom club Wolves.
A 3-2 defeat to Bournemouth in January shows Liverpool can score, but remain fragile in defence.
Tip: Both teams to score @ 4/9 (bet365)
Bet explanation: If Man Utd and Liverpool score at least one goal each, your bet wins regardless of which team snags the points.
Half-time result - Liverpool
I've saved the highest odds for my third and final bet. Here, I'm predicting Liverpool will enjoy a lead when going up the tunnel for half-time.
Again, it doesn't matter which team wins Sunday's match. If Liverpool out-score their hosts in the opening 45 minutes, you'll make a profit and can enjoy the second period. It's a big ask, but the numbers are encouraging.
Man Utd will have the backing of a huge crowd, but Liverpool have a history of starting well in this fixture, especially at Old Trafford.
The Reds won 3-0 on their last visit, and were winning 2-0 at the break, thanks to a Luis Diaz double. They also led 1-0 here in April 2024 in a match that ended 2-2. That's a strong start, but there's more to get excited about.
Backing Liverpool to win the first half proved a profitable pick in each of their last three visits to the Theatre of Dreams. It was also a strong bet in four of five, going back to Liverpool's famous 5-0 win here in the autumn of 2021.
Keita broke the deadlock on five minutes, before Jota and Salah struck to ensure the match was over by the turnaround.
Tip: Half-time result Liverpool win @ 21/10 (bet365)
Bet explanation: Liverpool must be leading at half time to ensure this bet is settled as a winner and you bank the profits.
Man Utd v Liverpool odds
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The odds, correct at the time of publication, are subject to change.