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From title challengers being tested away from home to local derbies with plenty on the line, it promises another action-packed weekend.
We’ve gone through the numbers and odds to pick out the best betting angles for some selected Premier League games.
Chelsea vs Fulham, Saturday, 12:30 BST
Chelsea rediscovered their scoring touch in emphatic fashion with a 5-1 win over West Ham, and they’ll look to carry that into this London derby.
Fulham stunned the Blues at Stamford Bridge last season, but that was their first away victory there in 21 attempts. Chelsea have lost just 8.3% of their Premier League games against Fulham, the lowest rate between two clubs with 20+ meetings.
With João Pedro and Estêvão already making headlines in the absence of Cole Palmer, it’s hard to see past another Chelsea win and at 1/2 with Bet365, the market clearly sees them as strong favourites to keep control of this derby.
Tip: Chelsea to win @1/2 with Bet365
Bet explanation: This bet wins if Chelsea beats Fulham regardless of the score.
Manchester United vs Burnley, Saturday, 15:00 BST
Old Trafford hasn’t been the fortress it once was, but Burnley’s visits here rarely end well. United have lost just one of their last 25 home games against the Clarets, and they’re unbeaten in their last 23 Premier League matches against promoted sides (W20 D3).
Burnley’s 2-0 win over Sunderland gave Scott Parker some relief, but they’ve not won back-to-back Premier League matches since 2022.
Even with Amorim’s men stuttering this season after picking just one point from the first two games, this looks like the ideal fixture for United to steady the ship. That’s why Bet365 have them priced at 33/100, odds that are reflective of a fixture United rarely slip up in.
Tip: Manchester United to win @33/100 with Bet365
Bet explanation: This bet wins if Manchester United beat Burnley regardless of the score.
Tottenham vs Bournemouth, Saturday, 15:00 BST
Tottenham have started fast under Thomas Frank, winning both opening games while keeping clean sheets. Yet Bournemouth have developed a knack for unsettling Spurs, earning more points against them since 2022 than in their first 10 Premier League meetings combined.
Spurs have attacking threats in Richarlison, Mohammed Kudus and Brennan Johnson, while the Cherries’ Antoine Semenyo has been involved in eight of their last 10 goals.
With both sides pushing forward and Bournemouth ranking among the league leaders in high turnovers, this fixture has goals written all over it, making the 83/100 odds on Over 2.5 & BTTS a high-value pick.
Tip: Over 2.5 goals & Both Teams to Score – Yes @83/100 with Bet365
Bet Explanation: This bet wins if Tottenham and Bournemouth score at least a goal, and there are at least three goals in the game.
Brighton vs Manchester City, Sunday, 14:00 BST
Last season, Brighton shocked City with a 2-1 win at the Amex, but Guardiola’s side arrive this time with a defensive record that speaks volumes - just one goal conceded in their last seven away league games.
Brighton are creating chances (3.91 xG across two matches) but struggling to finish, with the league’s worst finishing differential (-2.91).
With Phil Foden boasting six goals in six away appearances against Brighton and Erling Haaland making his 100th Premier League appearance, City have the edge to reclaim control and return to winning ways.
Tip: Manchester City win @4/5 with Bet365
Bet explanation: This bet wins if Manchester City beats Brighton regardless of the score.
Nottingham Forest vs West Ham, Sunday, 14:00 BST
The City Ground has become something of a nightmare for West Ham. The Hammers haven’t scored in their last four league visits there, and Forest come into this game having beaten them three times on the bounce.
Chris Wood loves this fixture with eight Premier League goals against West Ham, his joint-best tally versus any club.
Meanwhile, Potter’s West Ham have shipped eight goals in two games already this season, their worst start since 1954/55. Forest’s home form should be too strong here, reflecting the 7/10 odds on Nuno Espirito Santo’s men with Bet365.
Tip: Nottingham Forest to win @7/10 with Bet365
Bet explanation: This bet wins if Nottingham Forest beat West Ham regardless of the score.
Liverpool vs Arsenal, Sunday, 16:30 BST
This fixture rarely disappoints. Only Liverpool vs Spurs has produced more goals in Premier League history, and the last 20 meetings between Arsenal and Liverpool have seen 78 goals scored.
Arsenal arrive having kept clean sheets in both opening games, but Anfield has long been their graveyard as they are winless there in 12 attempts since 2012.
With Salah boasting 11 Premier League goals against the Gunners and Liverpool chasing a club-record scoring streak, this clash looks primed for goals, once again making Bet365’s 4/5 for Over 2.5 goals attractive.
Tip: Over 2.5 goals @4/5 with Bet365
Bet explanation: This bet wins if there are at least three goals scored in the match between Liverpool and Arsenal.
Aston Villa vs Crystal Palace, Sunday, 19:00 BST
Aston Villa’s home record is formidable as they’re unbeaten in their last 19 Premier League games at Villa Park (W11 D8).
Palace may have won big in their last meeting (4-1), but historically, they struggle there, with no wins at Villa Park since 2013.
Unai Emery’s side haven’t scored yet this season, but the home crowd and record should ensure they at least avoid defeat.
Palace’s Jean-Philippe Mateta does enjoy this fixture, scoring five goals in seven appearances against Villa, but the Villans’ unbeaten streak at home looks the safer angle.
Tip: Aston Villa or Draw @11/50 with Bet365
Bet explanation: This bet wins if Aston Villa avoids defeat against Crystal Palace.
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The odds, correct at the time of publication, are subject to change.