With a busy summer of new arrivals still bedding in, Roberto De Zerbi will nonetheless be optimistic that his side can show a much-improved response at home.
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Newcastle head south full of confidence of their own after a spirited 2-2 draw with Liverpool at St James' Park, a result that will sting slightly given Matthias Jaissle's side led twice before being pegged back.
Spurs haven't kept a clean sheet against the Magpies in 14 attempts, while Newcastle have won more away days at Tottenham than at any other Premier League ground, so neither side's recent defensive record offers much reassurance heading into this one.
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Tottenham v Newcastle tips
• Both teams to score - 53/100 with Bet365
• Over 2.5 goals - 61/100 with Bet365
• Yoane Wissa to have 2+ shots - 33/100 with Bet365
Odds courtesy of Bet365. Correct at the time of publication and subject to change.
Both teams to score
Every single one of the 62 previous Premier League meetings between these sides has produced at least one goal each, and Tottenham simply haven't been able to shut Newcastle out in this fixture, failing to keep a clean sheet in 14 straight attempts against them.
Neither side's defence looks in particularly good shape right now either. Spurs shipped three without reply against Brentford on the opening weekend, while Newcastle twice surrendered leads against Liverpool.
With Newcastle's recent away wins in London proving they can find the net on the road, 53/100 with Bet365 for both teams to score looks well worth backing.
Tip: Both teams to score @ 53/100
Bet explanation: This bet wins if both Tottenham Hotspur and Newcastle United score at least one goal in the match.
Over 2.5 goals
Tottenham have lost six of their last eight league meetings with Newcastle and haven't shown this season that they're defensively tight after the first game against Brentford.
Newcastle's own tendency to drop points from winning positions, more than any other side in the division since last season, points to a game with goals at both ends rather than a cagey, low-scoring affair.
With that in mind, Over 2.5 goals at 61/100 with Bet365 looks a fair reflection of how open this contest could be.
Bet explanation: This bet wins if there are three or more goals scored in total between Tottenham Hotspur and Newcastle United.
Yoane Wissa to have 2+ shots
Yoane Wissa has a real knack for this fixture, with three goal involvements in his last three Premier League appearances against Tottenham, including a goal and an assist at the Tottenham Hotspur Stadium back in May 2023.
He's also looked sharp and lively under Newcastle's new coaching setup, providing the assist for their opening goal against Liverpool.
Wissa's underlying numbers back up the volume too as he fired off four shots against Liverpool and missed a couple of big chances, while he also passed up an opportunity in a brief cameo against West Brom in the EFL Cup. He gets into good positions, making 33/100 with Bet365 for Wissa to register two or more shots a smart addition to the slip.
Tip: Yoane Wissa to have 2+ shots @ 33/100
Bet explanation: This bet wins if Yoane Wissa attempts two or more shots during the match.
Tottenham v Newcastle odds
• Tottenham - 5/4 with Bet365
• Draw - 11/4 with Bet365
• Newcastle - 19/10 with Bet365
Odds, correct at the time of publication, are subject to change.
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