Goalkeeper Alisson will also miss out, while City will be missing Rodri, Ruben Dias and Mateo Kovacic for what could be a decisive fixture in the title race.
Elsewhere, Arsenal look set to have several key players fit and firing again ahead of their match with West Ham - although Ben White remains out with a knee injury.
Chelsea captain Reece James is also facing some time out as a minor hamstring injury continues to cause issues, with the defender set to miss their clash with Aston Villa.
Find out who's missing and who's doubtful as the Premier League returns to kick-off a packed winter schedule this weekend:
Brighton v Southampton
WON'T PLAY
Baleba C. | Red Card
March S . | Knee Injury
Milner J. | Thigh Injury
O'Riley M. | Ankle Injury
Webster A. | Muscle Injury
Bazunu G. | Achilles Tendon Injury
Bednarek J. | Knee Injury
Lallana A. | Thigh Injury
Ramsdale A. | Finger Injury
Smallbone W. | Thigh Injury
Stewart R. | Thigh Injury
DOUBTS
Hinshelwood J. | Knee Injury
Kadioglu F. | Toe Injury
Onuachu P. | Injury
Brentford v Leicester
WON'T PLAY
Dasilva J. | Knee Injury
Henry R. | Knee Injury
Hickey A. | Thigh Injury
Norgaard C. | Red Card
Fatawu I. | Knee Injury
Opoku N. | Broken Leg
Pereira R. | Thigh Injury
Stolarczyk J. | Ankle Injury
DOUBTS
Gustavo Nunes | Back Injury
Ayew J. | Knee Injury
De Cordova-Reid B. | Calf Injury
Vardy J. | Back Injury
Winks H. | Injury
Crystal Palace v Newcastle
WON'T PLAY
Holding R. | Lacking Match Fitness
Matheus Franca | Muscle Injury
Nketiah E. | Thigh Injury
Riad C. | Knee Injury
Botman S. | Knee Injury
Krafth E. | Shoulder Injury
Lascelles J. | Knee Injury
DOUBTS
Eze E. | Thigh Injury
Wilson C. | Back Injury
Nottingham Forest v Ipswich
WON'T PLAY
Danilo | Ankle Injury
Sangare I. | Foot Injury
Donacien J. | Groin Injury
Hirst G. | Knee Injury
Ogbene C. | Calf Injury
DOUBTS
Anderson E. | Ankle Injury
Broadhead N. | Groin Injury
Burns W. | Knock
Greaves J. | Thigh Injury
Phillips K. | Injury
Taylor J. | Injury
Wolves v Bournemouth
WON'T PLAY
Chiwome L. | Ankle Injury
Gonzalez E. | Knee Injury
Kalajdzic S. | Knee Injury
Meupiyou B. | Injury
Mosquera Y. | Knee Injury
Traore B. | Knee Injury
Adams T. | Back Injury
Araujo J. | Thigh Injury
Scott A. | Knee Injury
Semenyo A. | Yellow Cards
Sinisterra L. | Injury
DOUBTS
Hwang Hee-Chan | Ankle Injury
Pedro Lima | Ankle Injury
West Ham v Arsenal
WON'T PLAY
Fullkrug N. | Achilles Tendon Injury
Tierney K. | Muscle Injury
Tomiyasu T. | Knee Injury
White B. | Knee Injury
DOUBTS
N/A
Chelsea v Aston Villa
WON'T PLAY
James R. | Thigh Injury
Kellyman O. | Muscle Injury
Onana A. | Foot Injury
Ramsey J. | Hamstring Injury
DOUBTS
N/A
Manchester United v Everton
WON'T PLAY
Evans J. | Knock
Lindelof V. | Muscle Injury
Maguire H. | Muscle Injury
Yoro L. | Ankle Injury
Broja A. | Calf Injury
Chermiti | Ankle Injury
Coleman S. | Thigh Injury
Garner J. | Lower Back Injury
Iroegbunam T. | Ankle Injury
DOUBTS
Branthwaite J. | Groin Injury
Tottenham v Fulham
WON'T PLAY
Bentancur R. | Suspended
Moore M. | Illness
Odobert W. | Thigh Injury
Richarlison | Thigh Injury
van de Ven M. | Thigh Injury
Vicario G. | Broken ankle
Reed H. | Knee Injury
DOUBTS
Romero C. | Ankle Injury
Liverpool v Manchester City
WON'T PLAY
Alisson | Hamstring Injury
Chiesa F. | Muscle Injury
Tsimikas K. | Ankle Injury
Bobb O. | Leg Injury
Dias R. | Injury
Kovacic M. | Injury
Rodri | Knee Injury
DOUBTS
Bradley C. | Muscle Injury
Konate I. | Knee Injury
Doku J. | Muscle Injury
Stones J. | Foot Injury