Spurs will also be without left-back Destiny Udogie, who joins a busy treatment room with a fresh muscle injury.
Elsewhere, Bukayo Saka is still a major doubt for Arsenal with a hip problem, while Jack Grealish's season is over after the Everton loanee underwent surgery on a foot fracture.
See who's missing and doubtful ahead of the next round of Premier League fixtures:
Chelsea v Leeds
WON'T PLAY
Colwill | Knee Injury
Essugo | Injury
Gittens | Muscle Injury
Lavia | Thigh Injury
Mudryk | Suspended
Stach | Hip Injury
Struijk | Hip Injury
DOUBTFUL
Adarabioyo | Muscle Injury
Jorgensen | Injury
Everton v Bournemouth
WON'T PLAY
Grealish | Foot Injury
Adams | Knee Injury
Doak | Hamstring Injury
Kluivert | Knee Injury
Soler | Injury
Tavernier | Thigh Injury
Tottenham v Newcastle
WON'T PLAY
Bentancur | Muscle Injury
Bergvall | Ankle Injury
Danso | Toe Injury
Davies | Ankle Injury
Kudus | Muscle Injury
Kulusevski | Knee Injury
Maddison | Knee Injury
Porro | Muscle Injury
Richarlison | Hamstring Injury
Romero | Red Card
Udogie | Muscle Injury
Joelinton | Groin Injury
Krafth | Knee Injury
Livramento | Hamstring Injury
Schar | Ankle Injury
DOUBTFUL
Spence | Calf Injury
Gordon | Thigh Injury
Miley | Knee Injury
West Ham v Manchester United
WON'T PLAY
Fabianski | Back Injury
Todibo | Red Card
De Ligt | Back Injury
Dorgu | Hamstring Injury
Mount | Knock
Aston Villa v Brighton
WON'T PLAY
Garcia | Thigh Injury
Kamara | Knee Injury
McGinn | Knee Injury
Tielemans | Ankle Injury
March | Knee Injury
Tzimas | Knee Injury
Webster | Knee Injury
Wieffer | Toe Injury
DOUBTFUL
Alysson | Injury
Ayari | Shoulder Injury
Van Hecke | Muscle Injury
Crystal Palace v Burnley
WON'T PLAY
Devenny | Ankle Injury
Doucoure | Knee Injury
Mateta | Coach's decision
Amdouni | Knee Injury
Beyer | Thigh Injury
Cullen | Knee Injury
Roberts | Groin Injury
Tresor | Ankle Injury
DOUBTFUL
Nketiah | Thigh Injury
Tuanzebe | Achilles Tendon Injury
Manchester City v Fulham
WON'T PLAY
Doku | Calf Injury
Gvardiol | Broken Leg
Kovacic | Heel Injury
Savinho | Health problems
Stones | Thigh Injury
Cairney | Calf Injury
Lukic | Injury
DOUBTFUL
Khusanov | Injury
Nottingham Forest v Wolves
WON'T PLAY
John Victor | Knee Injury
Sels | Groin Injury
Wood | Knee Injury
Toti | Hamstring Injury
DOUBTFUL
Murillo | Calf Injury
Savona | Knee Injury
Andre | Calf Injury
Hwang Hee-Chan | Injury
Sunderland v Liverpool
WON'T PLAY
Bi | Ankle Injury
Traore | Knee Injury
Xhaka | Ankle Injury
Bajcetic | Hamstring Injury
Bradley | Knee Injury
Frimpong | Injury
Isak | Broken Leg
Leoni | Knee Injury
Szoboszlai | Red Card
DOUBTFUL
Figueroa | Injury
Gomez | Injury
Brentford v Arsenal
WON'T PLAY
Carvalho | Knee Injury
Dasilva | Knee Injury
Milambo | Knee Injury
Dowman | Ankle Injury
Merino | Leg Injury
Odegaard | Injury
Saka | Injury
DOUBTFUL
Trossard | Injury