Udogie is set to be sidelined for around six weeks with a hamstring injury sustained in last week's draw with Wolves, while Bentancur is serving a one-game ban after picking up a fifth yellow card.
Elsewhere, Liverpool will be without Joe Gomez for their home tussle with Manchester United and beyond, while Marcus Rashford is out for the visitors due to illness.
Take a look at who's missing and who's a doubt ahead of the next set of Premier League fixtures:
Tottenham v Newcastle
WON'T PLAY
Bentancur R. | Yellow Cards
Davies B. | Thigh Injury
Moore M. | Illness
Odobert W. | Thigh Injury
Richarlison | Thigh Injury
Romero C. | Thigh Injury
Udogie D. | Thigh Injury
van de Ven M. | Thigh Injury
Vicario G. | Broken ankle
Krafth E. | Shoulder Injury
Lascelles J. | Knee Injury
Pope N. | Knee Injury
Schar F. | Yellow Cards
Wilson C. | Thigh Injury
DOUBTS
Botman S. | Injury
Aston Villa v Leicester
WON'T PLAY
Diego Carlos | Ankle Injury
Duran J. | Red Card
Rogers M. | Yellow Cards
Torres P. | Foot Injury
Fatawu I. | Knee Injury
Hermansen M. | Muscle Injury
McAteer K. | Knock
Ndidi W. | Thigh Injury
Opoku N. | Broken Leg
Pereira R. | Thigh Injury
DOUBTS
Faes W. | Injury
Bournemouth v Everton
WON'T PLAY
Araujo J. | Thigh Injury
Scott A. | Knee Injury
Senesi M. | Thigh Injury
Sinisterra L. | Thigh Injury
Smith A. | Leg Injury
Tavernier M. | Thigh Injury
Coleman S. | Calf Injury
Garner J. | Lower Back Injury
Iroegbunam T. | Ankle Injury
McNeil D. | Knee Injury
DOUBTS
None
Crystal Palace v Chelsea
WON'T PLAY
Chalobah T. | Loan agreement
Holding R. | Coach's decision
Hughes W. | Ankle Injury
Matheus Franca | Muscle Injury
Wharton A. | Groin Injury
Badiashile B. | Injury
Dewsbury-Hall K. | Knock
Fofana W. | Muscle Injury
Kellyman O. | Muscle Injury
Mudryk M. | Suspended
DOUBTS
Chukwuemeka C. | Illness
Lavia R. | Muscle Injury
Manchester City v West Ham
WON'T PLAY
Bobb O. | Leg Injury
Dias R. | Muscle Injury
Rodri | Knee Injury
Stones J. | Ankle Injury
Antonio M. | Inactive
Bowen J. | Broken Leg
Fabianski L. | Head Injury
DOUBTS
Ederson | Injury
Southampton v Brentford
WON'T PLAY
Bazunu G. | Achilles Tendon Injury
Fernandes M. | Yellow Cards
Smallbone W. | Thigh Injury
Stephens J. | Knock
Stewart R. | Thigh Injury
Ajer K. | Ankle Injury
Carvalho F. | Groin Injury
Dasilva J. | Knee Injury
Gustavo Nunes | Back Injury
Henry R. | Knee Injury
Hickey A. | Hamstring Injury
Mee B. | Injury
Pinnock E. | Thigh Injury
Thiago I. | Knee Injury
DOUBTS
Downes F. | Thigh Injury
Brighton v Arsenal
WON'T PLAY
Ferguson E. | Ankle Injury
Gomez D. | Inactive
Hinshelwood J. | Knee Injury
Kadioglu F. | Toe Injury
Milner J. | Thigh Injury
Welbeck D. | Ankle Injury
Saka B. | Thigh Injury
Sterling R. | Knee Injury
Timber J. | Yellow Cards
Tomiyasu T. | Knee Injury
White B. | Knee Injury
DOUBTS
Estupinan P. | Illness
Wieffer M. | Thigh Injury
Havertz K. | Illness
Fulham v Ipswich
WON'T PLAY
Berge S. | Ankle Injury
Nelson R. | Thigh Injury
Reed H. | Knee Injury
Tete K. | Knee Injury
Donacien J. | Ankle Injury
Hirst G. | Knee Injury
Ogbene C. | Calf Injury
Tuanzebe A. | Hamstring Injury
DOUBTS
Luongo M. | Illness
Liverpool v Manchester United
WON'T PLAY
Gomez J. | Thigh Injury
Lindelof V. | Injury
Mount M. | Leg Injury
Rashford M. | Coach's decision
Shaw L. | Calf Injury
DOUBTS
Bradley C. | Muscle Injury
Konate I. | Knee Injury
Wolves v Nottingham Forest
WON'T PLAY
Cunha M. | Suspended
Gonzalez E. | Knee Injury
Kalajdzic S. | Knee Injury
Lembikisa D. | Muscle Injury
Mosquera Y. | Knee Injury
Sangare I. | Foot Injury
DOUBTS
Lemina M. | Muscle Injury