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That win over Croatia was England's biggest-ever Nations League victory, but Thomas Tuchel's side know there's no margin for error after their opening defeat to Spain, and a slightly curious recent record at Wembley.
The Three Lions are winless in three home outings gives this game an added edge despite the gulf in quality on paper.
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The Czechs, meanwhile, have precious little to play for beyond pride, having lost each of their last seven League A fixtures and conceded at least twice in every one of them.
With two of their remaining games against top-four ranked nations, even a single point from this group now looks like a stretch, and a heavy defeat here would only deepen their relegation worries.
England v Czech Republic tips
• Anthony Gordon to score or assist - 53/100 with Bet365
• Over 2.5 goals - 9/25 with Bet365
• Harry Kane to have 2+ shots on target - 33/100 with Bet365
Odds courtesy of Bet365. Correct at the time of publication and subject to change.
Anthony Gordon to score or assist
Gordon was at the heart of England's rout of Croatia, scoring and providing an assist while arguably deserving even more from the game, and he's now found the net in three successive England appearances.
That kind of form and confidence rarely dries up overnight, especially against a Czech defence that's shipped goals for fun throughout this campaign.
With England expected to dominate possession and create plenty of chances in behind a shaky Czech backline, Gordon looks a strong bet to add to his impressive recent output. At 53/100 with Bet365, backing him to score or assist again looks a sensible way to get involved in another expected England rout.
Tip: Anthony Gordon to score or assist @ 53/100
Bet explanation: This bet wins if Anthony Gordon scores a goal or provides an assist during the match.
Over 2.5 goals
Goals have been a regular theme of England's recent matches, with six of their last seven Nations League games producing over 2.5, and eight of their last nine featuring at least two goals after half-time alone.
Given they've just put seven past Croatia, there's little reason to expect a sudden dip in firepower here.
The Czech Republic defence have conceded two or more goals in eight successive League A matches, and the historical head-to-head is similarly one-sided, with England's last home meeting against the Czechs finishing 5-0. Over 2.5 goals at 9/25 with Bet365 looks a thoroughly justified selection.
Bet explanation: This bet wins if there are three or more goals scored in total between England and the Czech Republic.
Harry Kane to have 2+ shots on target
Kane was among the goals again in the win over Croatia, netting twice to extend his scoring streak to all three games of this international break.
As England's focal point in attack, he's consistently the player most likely to test the opposition goalkeeper, and there's no reason to expect that to change against a Czech defence low on confidence and short on answers right now.
At 33/100 with Bet365, backing him for two or more shots on target looks a confident and well-supported pick given his current scoring form.
Tip: Harry Kane to have 2+ shots on target @ 33/100
Bet explanation: This bet wins if Harry Kane registers two or more shots on target during the match.
England vs Czech Republic odds
• England - 11/100 with Bet365
• Draw - 15/2 with Bet365
• Czech Republic - 20/1 with Bet365
Odds, correct at the time of publication, are subject to change.
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