A groin problem kept Yamal sidelined for Spain's games against Georgia and Bulgaria.
But after recovering from a groin injury and returning to club duty, Yamal is back in the reckoning to face Georgia on November 15th in Tbilisi followed by Turkey in Seville three days later.
Paris Saint-Germain midfielder Fabian Ruiz is also fit again after recovering from a leg injury suffered in the 2-1 Champions League defeat of Barcelona at the start of October.
Spain, the European champions, are top of Group E, with automatic qualification for next year's World Cup in their grasp.
While Yamal returns to national duty, Spain coach Luis de la Fuente will be missing his Barca teammate Pedri.
Also out of contention with injury are Real Madrid captain Dani Carvajal, Athletic Bilbao winger Nico Williams, and Atletico Madrid defender Robin Le Normand.