Kolisi will take the place of Paul de Villiers if he makes it through the week’s training after being omitted from the team beaten 33-16 by the All Blacks in the first Test in Johannesburg.
If he does not, De Villiers will keep his place, coach Rassie Erasmus said on Monday. Pieter-Steph du Toit has been named captain in what will be his 100th Test for the world champions.
The experienced half-back pairing of Handre Pollard and Cobus Reinach replace Feinberg-Mngomezulu, who was guilty of key handling errors, and the injured Grant Williams.
Winger Cheslin Kolbe is also out with what Erasmus termed a niggle and will be replaced by Ethan Hooker, which means Kurt-Lee Arendse switches from the left to right wing.
Switches on the bench include 39-year-old Deon Fourie as a back-up front row, while Thomas du Toit, Lood de Jager, and Cameron Hanekom also join hybrid Andre Esterhuizen.
Team: 15-Damian Willemse, 14-Kurt-Lee Arendse, 13-Jesse Kriel, 12-Damian de Allende, 11-Ethan Hooker, 10-Handre Pollard, 9-Cobus Reinach, 8-Jasper Wiese, 7-Pieter-Steph du Toit (c), 6-Siya Kolisi or Paul de Villiers, 5-Ruan Nortje, 4-Eben Etzebeth, 3-Wilco Louw, 2-Malcolm Marx, 1-Ox Nche.
Replacements: 16-Deon Fourie, 17-Gerhard Steenekamp, 18-Thomas du Toit, 19-Lood de Jager, 20-Andre Esterhuizen, 21-Cameron Hanekom, 22-Morne van den Berg, 23-Sacha Feinberg-Mngomezulu.