Pogacar attacked with twelve kilometres left, and while Jonas Vingegaard tried to stick to his rear wheel, he couldn't match the speed of the Slovenian rider.
Florian Lipowitz also fought to close the gap to Pogacar, while Remco Evenepoel and Tobias Johannessen were chasing further back.
Vingegaard received no help from Lipowitz in trying to close the gap, as all the hard work was handed to the Dane.
Vingegaard then dropped Lipowitz at the ten-kilometre mark and still had the world champion in his yellow race leader jersey in his sight.
With eight kilometres left, Pogacar was eighteen seconds ahead of Vingegaard, while Lipowitz was 25 seconds back, and Evenepoel was almost a minute behind, together with Johannessen.
Vingegaard fought furiously to minimise the gap on the climb, but with 4.4 kilometres left, the Danish rider from Team Visma was twenty seconds behind Pogacar.
Lipowitz had not thrown in the towel but was still chasing 54 seconds behind, while Evenepoel was almost 01:30 minutes behind the leading rider, Pogacar, who even looked like he could go up a gear if needed.
The UAE Team Emirates rider continued increasing his advantage as he approached the finish line at the summit of Valmeinier 1800, and Pogacar crossed the finish line in superior fashion to take his third stage victory in this year’s Critérium du Dauphiné.
Vingegaard chased to the end and on the final kilometre, managed to cut the gap severely as he finished in second place, 14 seconds after Pogacar.
Pogacar increased his lead in the general classification. Vingegaard remains second, while Lipowitz is still third. Evenepoel is fourth on the GC, while Matteo Jorgenson is fifth.