Winger Tom Roebuck scored twice in the second half to boost his chances of making the England squad for the November internationals.
Arron Reed's early brace, a penalty try and a Will Addison score saw Alex Sanderson's Sale establish a 28-3 interval lead to clinch the bonus point before half-time.
Roebuck then seized centre stage with his double after the break, while the visitors claimed a consolation try through captain Callum Chick.