The 31-year-old No. 8, who won his first cap in November, features in a revamped back row following last week's 48-7 thrashing by England - Wales' 12th successive Six Nations defeat and their 22nd loss in 24 Tests.
Tandy has made four personnel changes and two positional switches following the Twickenham trouncing, with props Rhys Carre and Tomas Francis replacing Nicky Smith and Archie Griffin in the front row.
The only change behind the scrum sees Joe Hawkins come in for Ben Thomas at inside centre.
In the back row, Aaron Wainwright and Alex Mann - who started against England - have been moved to accommodate the incoming Cracknell.
Reigning champions France began their title defence with a commanding 36-14 win at home to Ireland.
Wales (15-1)
Louis Rees-Zammit, Ellis Mee, Eddie James, Joe Hawkins, Josh Adams, Dan Edwards, Tomos Williams; Olly Cracknell, Alex Mann, Aaron Wainwright; Adam Beard, Dafydd Jenkins; Tomas Francis, Dewi Lake (capt), Rhys Carre
Replacements: Ryan Elias, Nicky Smith, Archie Griffin, Ben Carter, Taine Plumtree, Kieran Hardy, Jarrod Evans, Mason Grady
Coach: Steve Tandy (WAL)