France lead the standings with 15 points from second-placed Scotland on 11, and are in a strong position to retain the title. Italy remained in fifth place on five points.
France burst into a 19-0 lead at the Stade Pierre-Mauroy with tries from Louis Bielle-Biarrey, Emmanuel Meafou and Tomas Ramos to put them comfortably ahead before Ange Capuozzo dotted down for Italy to make it 19-8 at half-time.
Debutant winger Gael Drean and centre Emilien Gailleton added two more French tries in the second half.
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More to follow.