Gregor Townsend has made three changes to the side that kicked off in a 30-21 win over England in Edinburgh, with Bath centre Cameron Redpath replacing the injured Sione Tuipulotu and Saracens flanker Andy Christie given a first Test start in place of benched former captain Jamie Ritchie.

Scrum-half Ali Price, yet to feature in the tournament, is among Scotland's replacements for the match at Rome's Stadio Olimpico.

Scotland have won two of their three games so far, with victories over Wales and England either side of an agonising loss to France.

Italy drew 13-13 with France in the third round following defeats by England and reigning champions Ireland.

Scotland (15-1)

Blair Kinghorn; Kyle Steyn, Huw Jones, Cameron Redpath, Duhan van der Merwe; Finn Russell (co-capt, George Horne; Jack Dempsey, Rory Darge (co-capt), Andy Christie; Scott Cummings, Grant Gilchrist; Zander Fagerson, George Turner, Pierre Schoeman

Replacements: Ewan Ashman, Alec Hepburn, Elliot Millar-Mills, Sam Skinner, Jamie Ritchie, Matt Fagerson, Ali Price, Kyle Rowe

Coach: Gregor Townsend (SCO)