Three straight defeats have left England head coach Steve Borthwick's job seemingly hanging by a thread, while the team has come in for heavy criticism.
But Itoje, 31, believes that despite his team slumping to a first-ever defeat to Italy on the back of thumping losses against Scotland and Ireland, the future remains bright.
"Despite the losses, how I feel at the moment hasn't actually changed since the start of the competition," he said in Paris ahead of this weekend's final Six Nations match against France.
"I think this team is going somewhere and I'm desperate to be a part of it, and I think this team can beat pretty much every team we play if we get ourselves right."
Itoje made his debut in the 2016 Six Nations tournament as a substitute against Italy before starting in their final three matches - including the last time England won in Paris.
In half of the 10 matches between the teams since then, the result has been decided by three points or fewer.
"Our games against France are always tight," said Itoje.
"If anything, what this campaign has shown is that anyone can beat anyone on the day."
Although several results in this year's tournament have been lopsided, there has been a huge amount of unpredictability.
Scotland lost to Italy and their narrow victory over rock-bottom Wales was a much tighter affair than their wins over France and England.
"Just because we haven't won the last game or the last couple of games, doesn't mean we can't win the next one," said Itoje, whose team looks likely to finish this campaign in fifth.
"I truly believe this team has a high ceiling," he added.
'Necessary' pain
England lost five matches in a row in 2024, but in 2025 they won 11 straight before this tournament began.
Leading up to the 2023 World Cup, England were on a run of just six wins in 19 matches, but ended up two minutes away from reaching the final.
"We have been in similar situations before and that hasn't held us back in terms of what we can then go on and do," said Itoje.
"There are lessons to be learned from the games and perhaps it was necessary for us to go through this to be the team we want to be in due course."
England's forwards coach Joe El-Abd pointed to the team's ability to get into the opposition 22 as evidence that some parts of their game are working.
"It's like in football, you have loads of shots (but) if you don't score, obviously it puts you in danger of conceding at the other end," said El-Abd, whose brother Adam was a professional footballer.
"We're getting into the 22, which shows that part of our game is working to create the opportunities.
"The next step is to finish them off."