Men's top seed Carlos Alcaraz will play unseeded Australian Adam Walton in the Spaniard's quest for a first title in Melbourne to become the youngest man to complete the career Grand Slam.
At the draw ceremony at Melbourne Park on Thursday, 10-times champion Novak Djokovic, the fourth seed, was bracketed next to 71st-ranked Spaniard Pedro Martinez.
Serb Djokovic is gunning for the elusive record 25th Grand Slam title.
Women's second seed Iga Swiatek will meet a qualifier, while third seed Coco Gauff will play 55th-ranked Uzbek Kamilla Rakhimova.
Defending champion Madison Keys will face unseeded Ukrainian Oleksandra Oliynykova.