The Belarusian, who beat Amanda Anisimova to win the US Open for the second year running 10 days ago, will miss the WTA 1000 event in Beijing, which begins on September 24th.
"Aryna has not fully recovered from the injury she sustained during the US Open, (and) will miss the 2025 China Open," organisers announced.
Sabalenka, who reached the quarter-finals in Beijing last year, said on China social media platform Weibo that she was "very sad" to announce her withdrawal after "sustaining a small injury" at Flushing Meadows.
"I am going to focus on recovery, and strive to quickly return to the court at 100 per cent," she added.
Sabalenka is scheduled to defend her title next month at the Wuhan Open, the final 1000 WTA tournament of 2025.
"I can't wait to see my Chinese fans soon," added the 27-year-old. "I look forward to returning to Beijing next year."