The Australian, who chalked up his 200th tour-level hard-court win in his first-round victory against Roman Safiullin, showed off his pace around the court as he brushed past the Dutch qualifier in two hours, saving all four break points he faced.
It is the third time in successive tournaments that De Minaur has reached the quarter-final stage.
At the Australian Open he bumped up against eventual winner Jannik Sinner in the last eight and in Rotterdam earlier this month he went all the way to the final before succumbing in three sets to Carlos Alcaraz.
Chasing his first trophy of the season, De Minaur, ranked No.8 in the world, now faces the Russian Andrey Rublev who beat Nuno Borges 6-3, 6-4.
A Doha winner in 2020, Rublev has also been on a decent run of late, reaching the semi-finals in Montpellier and quarters in Rotterdam.
Alcaraz meets young Italian Luca Nardi later on Wednesday.