Friday's draw also pitched defending champion Barbora Krejcikova, the 17th seed, against Alexandra Eala of the Philippines.
Third seed Jessica Pegula's first-round opponent is Italian qualifier Elisabetta Cocciaretto, while fourth seed Jasmine Paolini, runner-up last year, faces Anastasija Sevastova of Latvia.
Belarusian Sabalenka could meet Paolini in the semi-finals while Gauff is in line for a clash with fellow American Pegula.
British number one Emma Raducanu faces an intriguing opening round match against compatriot Mingge Xu, one of three British teenage wildcards in the draw.