Jones, 31, who won gold at London 2012 and Rio 2016, will be trained by former British and Commonwealth champion Stephen Smith in Liverpool.
"Taekwondo has given me everything - an incredible journey, unforgettable memories and the honour of representing my country on the biggest stage," she said.
"I've given everything to taekwondo and I'm now ready for a new challenge. Boxing has always fascinated me and I'm excited to test myself in a completely different arena."
Jones was only 19 when she won gold in the -57kg category in London and repeated the feat four years later before going on to clinch an elusive first world title in Manchester in 2019.
The build-up to her fourth Olympics in Paris last year was overshadowed by controversy over a missed drugs test in December 2023, for which she ultimately avoided a ban after UK Anti-Doping found she had committed a no-fault violation on confidential medical grounds.
She exited in the first round at the Paris Games.
Smith believes Jones has the tools for her new sport.
"Jade is a born fighter - she's proven that time and time again in taekwondo," said Smith.
"Her athleticism, dedication and winning mentality are second to none. It's an honour to be working with her and I have no doubt she has what it takes to make a serious impact in boxing."