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Their most famous meeting came in 2020, when Atletico dramatically eliminated the Reds after extra time at Anfield.
Now, they meet again with both sides entering the new European campaign in contrasting domestic form.
Liverpool are flying high with a perfect start under Arne Slot, while Diego Simeone’s men only picked up their first win of the season last weekend.
Liverpool – Atletico Madrid, Wednesday, 8:00 pm
Liverpool v Atletico Madrid tips
• Liverpool to win – 57/100 with Bet365
• Both teams to score – 7/10 with Bet365
• Second half to have most goals (most booking points) – 1/1 with Bet365
Odds courtesy of bet365. Correct at the time of publication and subject to change.
Liverpool to win
The Reds have turned Anfield back into a fortress in Europe, winning all four of their home league phase matches last season by a combined score of 10-1.
That included a 2-0 win over Real Madrid, proof that they can overcome even the most tactically stubborn Spanish sides.
Atletico, meanwhile, have only one win in their last eight Champions League matches against English opposition. At 57/100 with Bet365, Liverpool to win feels a strong option, particularly given their streak of 14 straight home wins in European group or league phase fixtures.
Bet explanation: This bet wins if Liverpool beats Atletico Madrid regardless of the scoreline.
Both teams to score
While Liverpool look well placed to collect three points, Atletico’s attacking record cannot be ignored.
Simeone’s men have scored in 15 of their last 16 league phase matches, and Antoine Griezmann remains their talisman with 51 goal contributions in the competition.
With Atletico also finding the net in each of their games this season, BTTS at 7/10 on Bet365 looks well worth backing.
Tip: Both teams to score @7/10
Bet explanation: This bet wins if Liverpool and Atletico Madrid score at least a goal each.
Second half to have most goals
If recent trends are any guide, the real drama will unfold after the break.
Eleven of the last 13 goals in Liverpool matches have come in the second half, while Atletico often grow into Champions League fixtures, scoring 17 goals in just five group-stage wins last season.
Both sides are well-drilled defensively early on, but games between them tend to open up later as seen in their dramatic 2020 showdown at Anfield. At even money (1/1) with Bet365, backing the second half to produce the most goals offers real value to double your stake.
Tip: Second half to have most goals @1/1 with Bet365
Bet explanation: This bet wins if more goals are scored in the second half than the first half of the Liverpool vs Atletico Madrid game.
Liverpool v Atletico Madrid odds
• Liverpool – 57/100 with Bet365
• Draw – 16/5 with Bet365
• Atletico Madrid – 9/2 with Bet365
Odds, correct at the time of publication, are subject to change.
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The odds, correct at the time of publication, are subject to change.