Napoli v Arsenal: Champions League predictions, best bets and odds

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The opening round of matches in the 2026/27 UEFA Champions League continues Wednesday evening, with six more games on the schedule.

Followers will see some potential champions in action, including Barcelona, Liverpool, and three-in-a-row-chasing PSG. With all fixtures broadcast live and major bookmakers offering pre-game betting, there’s plenty to keep you entertained.

Browse our list of online betting partners, join your favourite, and secure a welcome bonus free bet ahead of kick-off.

On this page, experienced football betting writer Frank Monkhouse walks you through his Napoli v Arsenal preview and predictions. Each pick is led by the latest stats and trends available now on the Flashscore app and website.

Napoli v Arsenal betting tips

Arsenal or draw @ 2/11 (bet365)

Under 3.5 goals @ 1/3 (bet365)

De Bruyne shot on target @ 10/11 (bet365)

Odds courtesy of bet365. Correct at the time of publication and subject to change. 

Double chance - Arsenal or draw

My first of three suggested bets at the iconic Stadio Diego Armando Maradona is on the English Premier League side to avoid defeat.

When betting on the match-winner market, you have a one-in-three chance of making a profit. Your pick works against the draw and the opponent. When using the double chance betting market, you have a two-in-three chance of beating the bookies.

You’ll boost your betting balance if Arsenal beat Napoli or the night ends in a draw. A thrilling 3-0 victory for the Gunners is just as good as a boring 0-0 draw.

Head-to-head stats on the Flashscore app show Napoli and Arsenal have met four times previously. Interestingly, Arsenal have won all but one of those games, with Napoli taking the spare back in 2013.

In the most recent encounters, the Italians and English sides played home and away in 2019. Arsenal won 2-0 in London, and 1-0 in Naples. It’s also worth knowing that the Brits kept a clean sheet in each of the three wins mentioned.

You may remember that Arsenal were the only team in last season’s UCL to avoid defeat in regulation time. Mikel Arteta’s Premier League champions won 11 and drew 4. They face a tough opener on Italian soil, but I’m confident that it won’t be a wasted journey. 

Back Arsenal to take at least a point from this match. The odds offered on this wager make it perfect for midweek accumulators and Napoli v Arsenal Bet Builders.

Tip: Arsenal or draw @ 2/11 (bet365)

Bet explanation: You’ll make a profit from this match on any result other than a win for the home team.

Total goals - Under 3.5

Moving away from predicting the winning team, I head into the ever-popular total goals market.

Back Napoli v Arsenal to produce fewer than four goals. The winning team, scorers, and time of the goals don’t matter too much here. If Wednesday’s match ends with three goals or less, you’ll be celebrating a profit.

Sticking with the H2H for now, we see that a bet on under 3.5 goals landed in each of the previous four meetings. Those matches finished 2-0, 2-0, 2-0, and 1-0. 

Napoli have played three games in the Italian Serie A, with under 3.5 goals proving a winning bet twice. In the English Premier League, Arsenal have beaten Chelsea 2-1, Aston Villa 1-0, and Coventry City 3-0.

Arsenal impressed everyone who watched their march to last season’s UCL final, especially defensively. Despite playing 15 games, the team from North London conceded the fewest goals of any club, allowing just 7. 

Arsenal’s xG faced per game was no higher than 0.9, which was also the lowest total of any team competing.

Need more convincing before risking your stake? I’ve got you covered.

Arsenal goalkeeper David Raya kept a clean sheet in 53 per cent of his starts in this tournament. That’s better than any other UCL goalkeeper who has played at least 25 games.

Arteta and his coaching staff know that to stand any chance of taking three points back to the UK capital, they need a strong and reliable defence.

Tip: Under 3.5 goals @ 1/3 (bet365)

Bet explanation: Napoli v Arsenal must end with fewer than four goals scored by both teams combined.

1+ shots on target - De Bruyne

I’ll round off my three Napoli v Arsenal Champions League predictions with a pick at slightly higher odds. You can follow this one as a single or add it to small multiples.

Here, we’re backing Napoli’s Kevin De Bruyne to have at least one shot on target during Wednesday evening’s match.

It doesn’t matter if the 35-year-old ex-Chelsea and Manchester City midfielder scores a stunning strike or his tame effort rolls back to the visiting goalkeeper. If De Bruyne has a shot on target, your bet wins.

I was delighted at the odds available on De Bruyne 1+ shots on target. Expecting a price of around 1/2 or 4/9, I was pleasantly surprised to see bet365 offering 10/11. That’s too good to ignore, and is a bet that remains live for the entire time Kevin is on the field of play.

Football fans and followers of the Premier League know De Bruyne has experience of playing against Arsenal. The Belgian has been directly involved in a dozen goals in his previous 17 meetings with the Gunners in all competitions. 

Eight goals and four assists, including five in his last three versus Arsenal, make for pleasant reading. However, it’s important to remember that backers don’t need De Bruyne to score, just have a shot on target.

Tip: De Bruyne 1+ shots on target @ 10/11 (bet365)

Bet explanation: Kevin De Bruyne must get a shot on target at any stage of the match against Arsenal.

Napoli v Arsenal: Match result odds

Napoli win @ 15/4 (bet365)

Draw @ 27/10 (bet365)

Arsenal win @ 3/4 (bet365)