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Betis, who have won every home match they have played this season, host Barcelona, who remain unbeaten after winning all ten of their fixtures across all competitions. It is undoubtedly one of this week's standout matches across Europe's domestic leagues.
Currently assuming third position in LaLiga, Betis welcome the leaders. Both sides will have to rotate their squads due to a congested fixture schedule, which throws up some challenging assignments for Hansi Flick's men in particular.
Barça travel to Paris to face Champions League holders Paris Saint-Germain, before hosting arch-rivals Real Madrid next weekend.
Here are our predictions for Real Betis vs. Barcelona.
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Real Betis vs Barcelona – Predictions
Over 2.5 Goals and Both Teams to Score (BTTS): 8/15 (bet365)
Álvaro Valles Over 2.5 Saves and Joan García Over 1.5 Saves: 4/7 (bet365)
Barcelona to score in both halves: 8/11 (bet365)
These odds were correct at the time of publication and may change.
Three or more goals and both teams to score
We believe this is an attractive bet.
These are two of the top four scorers in the division. Five of their last six meetings have produced three or more goals, with both teams scoring in all of these contests.
The same could be said about each of their eight most recent clashes in Seville, so don't be surprised if we see another goal fest at the Estadio de La Cartuja, where Barcelona recorded an epic 5-3 triumph last season.
The same stats also apply to three of Real Betis last five matches and five of Barça's last six.
Prediction: Over 2.5 Goals and Both Teams to Score (BTTS): 8/15 (bet365)
Explanation: This bet will land if there are three or more goals scored in the match, providing both teams find the net.
Goalkeepers to play a key role
Given that Real Betis and Barcelona love to play attractive attacking football, we can expect plenty of action in both penalty boxes. Therefore, it's set to be a busy evening for goalkeeping duo Álvaro Vallés and Joan García, who are both renowned for their outstanding shot-stopping capabilities.
Vallés has made three or more saves in five of his last six outings across all competitions, as well as in four of his most recent five league matches.
Meanwhile, García has recorded at least two saves in each of his last three LaLiga appearances, something he also achieved during Tuesday's victory over Galatasaray in Istanbul.
Therefore, dipping into two goalkeeping markets is a good way to access some attractive odds.
Prediction: Álvaro Valles Over 2.5 Saves and Joan García Over 1.5 Saves: 4/7 (bet365)
Explanation: This bet will land if Álvaro Valles records three or more saves and Joan García makes at least two saves.
Barça to score before and after the interval
Barcelona have scored in both halves in every match they've played this season. The Catalans have also found the net in both halves in eight of their last ten meetings with Betis, including each of the last three league encounters hosted in Seville.
It's also worth noting that Betis don't boast a strong defensive record despite their impressive start to the campaign, having conceded more than one goal per game on average.
Prediction: Barcelona to score in both halves: 8/11 (bet365)
Explanation: This bet lands if Barcelona score in the first half and second half, regardless of the final result.
Real Betis vs. Barcelona – Match Result odds
These odds were correct at the time of publication and may change.
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