Liverpool can ill afford to lose the 25-year-old with the club already suffering several injury setbacks ahead of the new Premier League season.
Defender Joe Gomez is expected to miss the start of the campaign after suffering a muscle injury in their win over Sunderland, while Conor Bradley, Hugo Ekitike and Giovanni Leoni remain sidelined as they continue to recover from injuries.
"Jeremie asked for the sub but I don't think it's an injury," Iraola told Liverpool media after the game.
"It was just some overload and I hope he's not injured in that way. I don't think we've lost anyone."
Spaniard Iraola, who joined Liverpool in June after Dutchman Arne Slot was sacked, said the match had provided valuable lessons as they concluded their US tour.
"Obviously it's not the result you want but I think it was probably the most useful friendly we played – in a positive way in the first half and in a negative way in the second half," he added.
"We've learned a lot from today and I think we can take good conclusions and solve some things."
Liverpool, who finished fifth last term, visit Newcastle United in their opening Premier League fixture on August 23rd.