The Welshman currently has 33 points to his name with Netherlands' Michael van Gerwen following close behind on 29.
Night 14 will give darts fans an eye-catching affair as the duo are slated to lock horns in the last quarter-final at the AO Arena.
Speaking ahead of their clash, Van Gerwen stoked the flames. "(Price is in) fantastic form, but still has problems beating me," he said, via the Love the Darts podcast.
"Of course, I'm the best player," the Dutchman added. "I'm not playing my best and still the best players at the moment have the biggest problems with me - I'm just waiting (for it) to click."
There is yet another exciting match-up in the quarters as world number one Michael Smith is in action against fellow Englishman Nathan Aspinall.
Completing the round, Belgium's Dimitri van den Bergh contests Chris Dobey while fan-favourite Peter Wright takes on Jonny Clayton.
Quarter-finals
Wright v Clayton (19:10 BST)
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Dobey v Van Den Bergh (19:40 BST)
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Smith v Aspinall (20:10 BST)
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Price v Van Gerwen (20:40 BST)
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