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Unai Emery's side have also won all three previous meetings with Fenerbahçe, a record that should give them plenty of belief against a Turkish side who've been in good form of late.
Villa's struggles in the Premier League have been well-documented, and a 2-2 draw with Brentford at the weekend keeps them stuck in the bottom half of the table.
Europe, however, has been a very different story as their 3-2 win over Brugge was their 14th victory in major European competition since the start of last season, more than any other side, and they've now won ten European home matches in a row.
Fenerbahçe, meanwhile, come into the game having kept three successive clean sheets and hammered opponents in domestic action, but their Champions League record remains a sore point.
They haven't won any of their last eight matches in the main competition, and another failure to win here would equal their longest-ever winless run in the European Cup.
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Aston Villa - Fenerbahçe, Wednesday, 8:00 pm
Aston Villa vs Fenerbahçe tips
• Aston Villa to win - 61/100 with Bet365
• Over 2.5 goals - 61/100 with Bet365
• Nicolas Jackson to have 1+ shots on target - 1/4 with Bet365
Odds courtesy of Bet365. Correct at the time of publication and subject to change.
Aston Villa to win
Since the start of last season, Aston Villa have won more games than any other side in major European competition, winning 14 of 16, and they've taken maximum points in each of their last ten home games on the continent.
Against Fenerbahçe specifically, they're a perfect three from three without conceding a single goal, the most recent a 1-0 win away from home in the Europa League earlier this year.
Fenerbahçe, by contrast, haven't won any of their last eight Champions League matches and have won just two of their last eleven against English opposition. With Villa's home form in Europe so strong, backing the hosts at 61/100 with Bet365 looks a sound approach.
Tip: Aston Villa to win @ 61/100
Bet explanation: This bet wins if Aston Villa beat Fenerbahçe regardless of the scoreline.
Over 2.5 goals
Villa have scored three or more in five of their last seven European matches, while Fenerbahçe have been trailing at half-time in eight of their last ten Champions League games, forcing them to chase matches and leaving plenty of space for goals to flow at both ends.
The Turkish side's form has seen them score freely too, putting eleven past opponents in their last two league wins.
With Villa at their most comfortable on the European stage and Fenerbahçe likely to need to take risks to end their winless run, a goal-filled contest looks probable. Over 2.5 goals at 61/100 with Bet365 looks a sensible way to back that expectation.
Bet explanation: This bet wins if there are three or more goals scored in total between Aston Villa and Fenerbahçe.
Nicolas Jackson to have 1+ shots on target
Jackson has been a revelation in Europe's top competition, scoring three goals and providing two assists in four Champions League starts, and recording two or more shots on target in three of those four games.
That kind of consistency makes him a strong candidate to test the goalkeeper again here. Against a Fenerbahçe side with one of the oldest starting line-ups in the competition and a habit of falling behind early, Jackson should find opportunities to get at the defence.
At 1/4 with Bet365, backing him for at least one shot on target looks a confident selection.
Tip: Nicolas Jackson to have 1+ shots on target @ 1/4
Bet explanation: This bet wins if Nicolas Jackson registers at least one shot on target during the match.
Aston Villa vs Fenerbahçe odds
• Aston Villa - 61/100 with Bet365
• Draw - 3/1 with Bet365
• Fenerbahçe - 9/2 with Bet365
Odds, correct at the time of publication, are subject to change.
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