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The Metropolitano will host its biggest night of the first half of the season when Bayern Munich, one of the best teams in the world at present, come to town.
The Germans' arrival represents a huge test for Simeone's side, during a week in which Barça will also visit the rojiblancos' home ground.
Atletico still have time on their side, but with just four points, they would do well not to come away empty-handed. Here are our tips for the match.
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Atletico Madrid vs Bayern Munich Tips
Both teams to score and over 2.5 goals - 4/7 @ bet365
Bayern to win either half - 4/9 @ bet365
Harry Kane to score or assist - 4/7 @ bet365
Odds correct at time of writing, subject to change.
Both teams to score and three or more total goals
We believe this is a clear pick. Bayern have one of the most devastating attacks on the planet, although they also concede a fair number of goals.
Atletico, particularly at home, have been finding the net consistently too, having failed to score in just one competitive match this season: their league defeat away to Athletic Club.
In addition, Bayern's last ten competitive matches have all ended with more than 2.5 goals, suggesting the same could happen at the Metropolitano.
Tip: Both teams to score and over 2.5 goals - 4/7 @ bet365
Bet Explanation: This bet wins if the match produces three or more total goals and both teams score at least once.
Bayern to win either half
Bayern, who are unbeaten this year, have won at least one half in all of their competitive fixtures apart from the goalless league draw against Schalke and the 2-2 home draw against Arsenal in this competition.
Atletico, meanwhile, have lost at least one half in two of their three Champions League matches, although both instances came away from home. We also found that Bayern won at least one half in five of the last seven historical meetings between the two sides.
Tip: Bayern to win either half - 4/9 @ bet365
Bet Explanation: This bet wins if Bayern win at least one half of the match.
Kane, always Kane
The Ballon d'Or winner is enjoying a simply remarkable season, having scored or assisted in 13 of his last 14 matches in which he played more than half the game for club or country.
The English striker is also Bayern's penalty specialist. He is one of the German side's biggest threats, and his record since joining the legendary German club, averaging almost a goal per game across all competitions, proves it.
Tip: Harry Kane to score or assist - 4/7 @ bet365
Bet Explanation: This bet wins if Harry Kane scores at least one goal or provides an assist in the match.
Atletico Madrid vw Bayern odds
Atletico Madrid to win - 12/5 @ bet365
Bayern to win - 19/20 @ bet365
Odds correct at time of writing, subject to change.
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