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Their last Champions League outing ended in a humbling 4-2 home defeat to PSG, and this fixture gives Enzo Maresca's side a perfect chance to respond and climb back up the league phase table.
City bounced back in the Premier League with a 3-2 win over Ipswich at the weekend to keep their perfect domestic start going, and their record in this fixture type is formidable.
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They've never lost to a Greek side in four previous meetings, and no team from outside Europe's big five leagues has won at their ground in this competition since Basel in March 2018, with City winning 12 and drawing three of 15 such games since.
AEK arrive after a 3-1 defeat to Shakhtar that ended an 11-match unbeaten run, and the task ahead looks daunting. They have just one win in 26 away games in the European Cup and Champions League, and Greek clubs have returned from just one of 20 trips to English opposition with a win.
Manchester City vs AEK Athens tips
• Over 3.5 goals - 4/5 with Bet365
• Enzo Fernandez to have 1+ shot on target - 2/5 with Bet365
• Rayan Cherki to score or assist - 33/100 with Bet365
Odds courtesy of Bet365. Correct at the time of publication and subject to change.
Over 3.5 goals
City have scored an average of 3.1 goals per game in their 15-match unbeaten run against teams from outside the big five leagues in this competition, netting 46 times in total, and four of their last five competitive matches have produced more than 4.5 goals.
Their 4-2 loss to PSG and 3-2 win over Ipswich show how open their games have been recently. AEK have conceded two or more goals in nine of their last ten Champions League away games and shipped three against Shakhtar last time out.
Even if City make changes, there should be enough attacking quality and defensive uncertainty on show to make Over 3.5 goals at 4/5 with Bet365 appealing.
Tip: Over 3.5 goals @ 4/5
Bet explanation: This bet wins if there are four or more goals scored in total between Manchester City and AEK Athens.
Fernandez to have 1+ shot on target
With Antoine Semenyo and Iliman Ndiaye picking up knocks against Ipswich, Enzo Fernandez, who was rested at the weekend, could be handed a more advanced role.
That should encourage him to shoot more, and he has already managed three shots in each of City's opening two Champions League games.
With added responsibility in the final third against an AEK side who tend to concede plenty on their travels, there's every reason to expect him to test the goalkeeper. At 2/5 with Bet365, this looks a solid selection.
Tip: Enzo Fernandez to have 1+ shot on target @ 2/5
Bet explanation: This bet wins if Enzo Fernandez registers at least one shot on target during the match.
Cherki to score or assist
Rayan Cherki was rested over the weekend and looks set to get his opportunity here, with injuries to others opening up space in City's attack. He'll be aware of the increasing competition for places and eager to prove a point.
AEK shipped three goals against Shakhtar and have conceded two or more in nine of their last ten away games in the competition, which should give a creative player like Cherki plenty of room to make an impact.
At 33/100 with Bet365, backing him to score or assist looks a confident pick.
Tip: Rayan Cherki to score or assist @ 33/100
Bet explanation: This bet wins if Rayan Cherki scores a goal or provides an assist during the match.
Manchester City vs AEK Athens odds
• Manchester City - 83/1000 with Bet365
• Draw - 11/1 with Bet365
• AEK Athens - 20/1 with Bet365
Odds, correct at the time of publication, are subject to change.
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